Gene interactions and pathways from curated databases and text-mining

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IGF1R — PIK3R1

Pathways - manually collected, often from reviews:

  • BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway: IGF-1/IGF-1R complex (IGF1-IGF1R) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  • KEGG Focal adhesion: EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  • KEGG Pathways in cancer: IGF1R → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  • KEGG Glioma: IGF1R → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  • KEGG Glioma: IGF1R → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  • KEGG Prostate cancer: EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
    Mur et al., Endocrinology 2003
    Evidence: assay
  • WikiPathways Apoptosis: IGF1R → PIK3R1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Dilly et al., Invest Ophthalmol Vis Sci 2008 (Disease Models, Animal) : Light stress induced the activation of PI3K through activation and binding of IGF-1R , which leads to activation of the Akt survival pathway in photoreceptors
Park et al., Haematologica 2010 (Leukemia, Myeloid, Acute) : Constitutive PI3K activation is the result of autocrine IGF-1/IGF-1R signaling in 70 % of acute myeloid leukemia samples but specific inhibition of this pathway does not induce apoptosis
Chapuis et al., Haematologica 2010 (Blast Crisis...) : Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia : therapeutic value of neutralizing anti-IGF-1R antibody
He et al., Ann Oncol 2012 (Breast Neoplasms...) : Human epidermal growth factor receptor ( HER2 ), insulin receptor and IGF-I receptor involve the same PI3K/AKT/mTOR signaling, and different antidiabetic pharmacotherapy may differentially affect this pathway, leading to different prognoses of HER2+ breast cancer
Xie et al., Cancer cell international 2013 : Klotho is a tumor suppressor in gastric cancer, which regulates IGF-1R phosphorylation and the subsequent activation of IRS-1/PI3K/Akt/mTOR signaling, tumor cell proliferation, apoptosis, and autophagy
Molina-Arcas et al., Cancer Discov 2013 (Carcinoma, Non-Small-Cell Lung...) : PI3K pathway activity is dependent on basal IGF1R activity in KRAS-mutant, but not wild-type, lung cancer cell lines