◀ Back to PIK3R1
IGF1R — PIK3R1
Pathways - manually collected, often from reviews:
-
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway:
IGF-1/IGF-1R complex (IGF1-IGF1R)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
-
KEGG Focal adhesion:
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Pathways in cancer:
IGF1R
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Glioma:
IGF1R
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Glioma:
IGF1R
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Prostate cancer:
EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Mur et al., Endocrinology 2003
Evidence: assay
-
WikiPathways Apoptosis:
IGF1R
→
PIK3R1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Dilly et al., Invest Ophthalmol Vis Sci 2008
(Disease Models, Animal) :
Light stress
induced the activation of
PI3K through activation and binding of
IGF-1R , which leads to activation of the Akt survival pathway in photoreceptors
Park et al., Haematologica 2010
(Leukemia, Myeloid, Acute) :
Constitutive
PI3K activation is the
result of autocrine
IGF-1/IGF-1R signaling in 70 % of acute myeloid leukemia samples but specific inhibition of this pathway does not induce apoptosis
Chapuis et al., Haematologica 2010
(Blast Crisis...) :
Autocrine
IGF-1/IGF-1R signaling is
responsible for constitutive
PI3K/Akt activation in acute myeloid leukemia : therapeutic value of neutralizing anti-IGF-1R antibody
He et al., Ann Oncol 2012
(Breast Neoplasms...) :
Human epidermal growth factor receptor ( HER2 ), insulin receptor and
IGF-I receptor involve the same
PI3K/AKT/mTOR signaling, and different antidiabetic pharmacotherapy may differentially affect this pathway, leading to different prognoses of HER2+ breast cancer
Xie et al., Cancer cell international 2013
:
Klotho is a tumor suppressor in gastric cancer, which regulates
IGF-1R phosphorylation and the subsequent
activation of
IRS-1/PI3K/Akt/mTOR signaling, tumor cell proliferation, apoptosis, and autophagy
Molina-Arcas et al., Cancer Discov 2013
(Carcinoma, Non-Small-Cell Lung...) :
PI3K pathway activity is
dependent on basal
IGF1R activity in KRAS-mutant, but not wild-type, lung cancer cell lines