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IGF1R — SHC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SHC1 → IGF1R (increases, SHC1 Activity) Weng et al., Hum Mol Genet 2001*
  Evidence: Modified assertion
• BioCarta multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta/14-3-3 complex (IGF1R-YWHAH-IGF1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta the igf-1 receptor and longevity: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta complex (IGF1-IGF1R) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta igf-1 signaling pathway: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta complex (IGF1-IGF1R) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Focal adhesion: EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG Glioma: IGF1R → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG Glioma: IGF1R → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC mu (PRKD1) (modification, activates) Hermanto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → IGF-1R heterotetramer complex (IGF1R) (modification, activates)
  Kahlert et al., J Biol Chem 2000, Song et al., Proc Natl Acad Sci U S A 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) (modification, activates)
  Kahlert et al., J Biol Chem 2000, Song et al., Proc Natl Acad Sci U S A 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GTP complex (HRAS) (modification, activates)
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) → IGF-1R heterotetramer/IGF1/SHC/GRB10 complex (IGF1R-IGF1-SHC1-GRB10) (modification, collaborate)
  Morrione et al., Cancer Res 1996*, Dey et al., Mol Endocrinol 1996, O'Neill et al., J Biol Chem 1996, He et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) → SHC (SHC1) (modification, collaborate) Morrione et al., Cancer Res 1996*, Dey et al., Mol Endocrinol 1996, O'Neill et al., J Biol Chem 1996, He et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: GRB10 (GRB10) → IGF-1R heterotetramer/IGF1/SHC/GRB10 complex (IGF1R-IGF1-SHC1-GRB10) (modification, collaborate)
  Morrione et al., Cancer Res 1996*, Dey et al., Mol Endocrinol 1996, O'Neill et al., J Biol Chem 1996, He et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/SHC/GRB10 complex (IGF1R-IGF1-SHC1-GRB10) → SHC (SHC1) (modification, collaborate) Morrione et al., Cancer Res 1996*, Dey et al., Mol Endocrinol 1996, O'Neill et al., J Biol Chem 1996, He et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) (modification, collaborate)
  Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC delta (PRKCD) (modification, activates) Hermanto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) (modification, collaborate)
  
• NCI Pathway Database IGF1 pathway: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) (modification, collaborate)
  
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) → IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) (modification, collaborate)
  
• Reactome Reaction: IGF1R → SHC1 (indirect_complex) Hernández-Sánchez et al., J Biol Chem 1995*, Tartare-Deckert et al., J Biol Chem 1995*, Giorgetti et al., Eur J Biochem 1994*, Kim et al., J Biol Chem 1998
• Reactome Reaction: IGF1R → SHC1 (reaction) Hernández-Sánchez et al., J Biol Chem 1995*, Tartare-Deckert et al., J Biol Chem 1995*, Giorgetti et al., Eur J Biochem 1994*, Kim et al., J Biol Chem 1998
• WikiPathways Focal Adhesion: BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 → SHC1/SHC3 (activation)
• WikiPathways Insulin Signaling: IGF1R → SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: IGF1R — SHC1 Craparo et al., J Biol Chem 1995*
• IRef Bind_translation Interaction: IGF1R — SHC1 (experimental interaction detection) Craparo et al., J Biol Chem 1995*
• IRef Bind_translation Interaction: IGF1R — SHC1 (two hybrid) Craparo et al., J Biol Chem 1995*
• IRef Biogrid Interaction: IGF1R — SHC1 (physical association, affinity chromatography technology) Santen et al., Endocr Relat Cancer 2005*
• IRef Biogrid Interaction: IGF1R — SHC1 (direct interaction, two hybrid) Tartare-Deckert et al., J Biol Chem 1995*
• IRef Biogrid Interaction: IGF1R — SHC1 (physical association, affinity chromatography technology) Song et al., Proc Natl Acad Sci U S A 2004
• IRef Biogrid Interaction: IGF1R — SHC1 (direct interaction, two hybrid) Dey et al., Mol Endocrinol 1996
• IRef Hprd Interaction: Complex of ESR1-IGF1R-SHC1-IGF1R-ESR1-SHC1-SHC1-IGF1R-ESR1 (in vivo) Santen et al., Endocr Relat Cancer 2005*
• IRef Intact Interaction: IGF1R — SHC1 (physical association, two hybrid) Klammt et al., Biochem Biophys Res Commun 2005*
• IRef Intact Interaction: IGF1R — SHC1 (physical association, two hybrid) Craparo et al., J Biol Chem 1995*
• IRef Intact Interaction: IGF1R — SHC1 (physical association, far western blotting) Craparo et al., J Biol Chem 1995*
• IRef Ophid Interaction: IGF1R — SHC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Boney et al., Mol Endocrinol 2000 : IGF-I induces signaling pathways that involve IGF-I receptor mediated tyrosine phosphorylation of Shc and insulin receptor substrate 1 (IRS-1)
Takahashi et al., Endocrinology 1997 : Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts