Gene interactions and pathways from curated databases and text-mining

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GH1 — IGFALS

Text-mined interactions from Literome

Fukuda et al., Endocr J 2002 (Acromegaly...) : Like IGF-I and IGFBP-3, serum levels of ALS depend on growth hormone (GH)
Baxter et al., Horm Res 1996 (Hypoglycemia...) : Factors contributing to the defect are : ( 1 ) low ALS levels, secondary to suppressed growth hormone (GH) ; ( 2 ) defective IGFBP-3 binding to ALS ; ( 3 ) reduced ability of pro-IGF-II forms to complex normally, and ( 4 ) very high levels of other IGFBPs, including IGFBP-2 and IGFBP-6, which might limit the formation of complexes with IGFBP-3