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AKT3 — IGFBP1

Text-mined interactions from Literome

Mochizuki et al., Growth Horm IGF Res 2006 (Endometrial Neoplasms) : Although EGF stimulated HHUA cell proliferation and Akt phosphorylation, IGFBP-3 inhibited cell proliferation and Akt phosphorylation that had been stimulated by EGF
Fu et al., J Cell Physiol 2010 (MAP Kinase Signaling System...) : In contrast, IGFBP-6 had no effect on Akt phosphorylation and an Akt inhibitor had no effect on migration
Yin et al., J Clin Endocrinol Metab 2012 (Endometriosis...) : Moreover, inhibition of AKT with MK2206, an allosteric AKT inhibitor, dramatically increased the accumulation of nuclear FOXO1 as well as expression of IGFBP1
Cichy et al., J Biol Chem 1998 : Insulin lowers IGFBP-1 mRNA levels, inhibits IGFBP-1 promoter activity, and activates PKB/Akt in HepG2 hepatoma cells through a PI3K dependent, rapamycin-insensitive mechanism ... Constitutively active PI3K and PKB/Akt are each sufficient to mediate effects of insulin on the IGFBP-1 promoter in a nonadditive fashion