Gene interactions and pathways from curated databases and text-mining

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IKBKG — PIK3R1

Text-mined interactions from Literome

Chen et al., J Biol Chem 2007 : In conclusion, MEK1, TAK1, NF-kappa inducing kinase, and PI3K are required for iron induced IKK activation in hepatic macrophages and TAK1, PI3K, and p21ras physically interact in caveolae to initiate signal transduction
Zhu et al., Biochem Biophys Res Commun 2007 : PI3K is negatively regulated by PIK3IP1 , a novel p110 interacting protein
He et al., Cancer Res 2008 (Carcinoma, Hepatocellular...) : PIK3IP1 , a negative regulator of PI3K , suppresses the development of hepatocellular carcinoma
Comb et al., Mol Cell 2012 (Starvation) : Finally, leucine deprivation is shown to be necessary and sufficient for starvation induced, IKK mediated p85 phosphorylation and PI3K feedback inhibition
Chiron et al., Cell cycle (Georgetown, Tex.) 2013 (Lymphoma) : PIK3IP1 , a negative PI3K regulator , appears to mediate pG1 sensitization to PI3K inhibition ; it is markedly reduced in MCL tumor cells compared with normal peripheral B cells, profoundly induced in pG1 and required for pG1 sensitization to GS-1101