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IL10 — SLPI

Text-mined interactions from Literome

Jin et al., Methods 1998 (Inflammation) : The expression of SLPI was strongly enhanced by interleukin-10 and -6
Sano et al., Kekkaku 1999 : In this study, we examined the effects of SLPI on the production of a proinflammatory cytokine, TNF-alpha, and immunosupressive cytokines, IL-10 and transforming growth factor-beta ( TGF-beta ) by macrophages ( M phi s ), in response to lipopolysaccharide (LPS) mediated stimulation and M. avium complex ( MAC ) infection, using recombinant half sized SLPI ( 1/2 SLPI ) consisting of C-terminal domain ( Arg55-Ala107 ) of intact SLPI ... Half sized SLPI did not affect IL-10 production of LPS stimulated M phi s, while it caused slight enhancement of IL-10 production by MAC infected M phi s. M phi TGF-beta production was initiated in the middle phase ( day 7 ) of M phi cultivation and continued until day 14
Sano et al., Clin Exp Immunol 2000 : 1/2 SLPI significantly increased IL-10 and TGF-beta production by macrophages in response to a low dose as well as a high dose of LPS ... Reverse transcription-polymerase chain reaction analysis showed that 1/2 SLPI caused a significant increase in the expression of both IL-10 and TGF-beta mRNAs by LPS stimulated macrophages
Jin et al., Infect Immun 1998 (Lung Diseases...) : Two LPS induced proteins-interleukin-10 (IL-10) and IL-6-also induced SLPI , while TNF and IL-1beta did not