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CRK — IL12A

Text-mined interactions from Literome

Vidalain et al., EMBO J 2000 : We demonstrate that stimulation of Src family kinase within membrane rafts initiates a pathway implicating ERK activation, which leads to interleukin (IL)-1alpha/beta and IL-1Ra mRNA production and contributes to p38 dependent IL-12 mRNA production
Kesherwani et al., Cytokine 2007 : The expression of TNF-alpha, IL-1beta and IL-12 was down regulated in the presence of PD98059 and SB202190 in a dose dependent manner, suggesting the involvement of p42/44 and p38 in ConA induced production of TNF-alpha, IL-1beta and IL-12 by macrophages
Tassi et al., Immunity 2007 : p110gamma played a major role in receptor induced interferon-gamma (IFN-gamma) production through a pathway that involved the kinase ERK and 5-Lipoxigenase, which most likely generates lipid mediators activating GPRCs. Conversely, PI3Ks negatively regulated interleukin-12 (IL-12) and IL-18 induced IFN-gamma by modulating p38 kinase activation
Sommer et al., Vet Immunol Immunopathol 2009 : In uninfected cells, inhibition of MAPK revealed that CD40L mediated increase in IL-6 gene expression was dependent on activation of ERK1/2, while increases in IL-12p40 , iNOS, and IL-10 gene expression were dependent on activation of p38
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-12 p40, and the activation of ERK1/2 and p38