Gene interactions and pathways from curated databases and text-mining

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IL12A — IRF4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Liu et al., J Exp Med 2003 : Thus, IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of IL-12 p35 transcription in synergy with LPS mediated events
Lehtonen et al., Cytokine 2003 : IFN-alpha and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4 , and IRF-8 gene expression in human NK and T cells ... Both IFN-alpha and IL-12 strongly up-regulated IRF-1, IRF-4 , and IRF-8 mRNA and protein expression ... Both IFN-alpha and IL-12 strongly up-regulated IRF-1, IRF-4 , and IRF-8 mRNA and protein expression
Xiong et al., J Biol Chem 2005 : Furthermore, IRF-8 induced IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production