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IL12A — PIK3R1
Text-mined interactions from Literome
Fukao et al., Nat Immunol 2002
:
PI3K mediated negative feedback regulation of
IL-12 production in DCs
Williams et al., J Immunol 2004
(Disease Susceptibility...) :
Inhibition of
PI3K resulted in increased serum levels of IL1-beta, IL-2, IL-6, IL-10,
IL-12 , and TNF-alpha in septic mice
Waggoner et al., J Immunol 2005
:
Suppression of
IL-12 did not result from increased IL-10 or TGF-beta, but was
dependent on
PI3K activation
Yang et al., Clin Exp Immunol 2006
(MAP Kinase Signaling System...) :
The
enhancement of
IL-12 levels by inhibition of
PI 3-K and ERK 1/2 was not reversed by neutralization of TNF-alpha or addition of rhTNF-alpha, suggesting that the negative regulation of IL-12 is not mediated by concomitant TNF-alpha suppression
Kuo et al., J Immunol 2006
:
Our results reveal that class III PI3K specifically regulates CpG oligodeoxynucleotide ( ODN ) -induced cytokine and NO production as well as NF-kappaB activation, whereas class I
PI3K regulates both CpG ODN- and LPS induced
IL-12 production and NF-kappaB activation
Saegusa et al., Mol Immunol 2007
:
The enhancement
effect of
PI3K inhibitors on
IL-12 p70 production almost completely disappeared by the treatment with anti-IL-10 mAb ... These results suggest that
PI3K positively and negatively regulates the production of CpG-ODN induced IL-10 and IL-12 p70, respectively, and negatively
regulates IL-12 p70 production in macrophages through ERK mediated IL-10 induction
He et al., J Immunol 2006
:
Expression of
IL-12p40 required activation of the p38 MAPK and
PI3K
Liu et al., J Exp Med 2007
(Toxoplasmosis) :
We further show that DGKzeta negatively controls the phosphatidylinositol 3-kinase (PI3K)-Akt pathway and that inhibition of
PI3K activity or treatment with PA can
restore lipopolysaccharide induced
IL-12 production by DGKzeta-deficient Mphi
Usluoglu et al., Eur J Immunol 2007
:
Different signal pathways mediate LPS induced expression of
IL-12 and
involve PI3K , MAPK and the transcription factor NF-kappaB
Utsugi et al., J Immunol 2009
(MAP Kinase Signaling System) :
Knockdown of
PI3K p110alpha by siRNA
reduced LPS induced
IL-12 protein production in both cell types
Garcia et al., J Immunol 2009
:
In the present study, we demonstrate that
IL-12p70 induces IL-10 production from human memory CD4+ T cells via a
PI3K dependent signaling mechanism
Wenink et al., J Immunol 2009
:
The inhibitory effect of TLR2 on the release of TNF-alpha but not of
IL-12p70 was
mediated by
PI3K
Ishikawa et al., Nihon Arukoru Yakubutsu Igakkai Zasshi 2011
:
Alternatively, cytokine signaling studies indicate that
IL-12 production by DCs is negatively
regulated by
PI3K and GSK-3, but positively regulated by p38 MAPK, mTOR, and NF-kappa B
Miyazawa et al., J Biochem 2012
:
2011 ; 149 : 265-274 ) recently indicated that
PI3K activated downstream of C5a anaphylatoxin does not
affect the induction of
IL-12 by TLR, although C5a efficiently inhibits the induction, in macrophages