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ICAM1 — IL12B

Text-mined interactions from Literome

Yue et al., Eur J Immunol 1999 (Melanoma) : Preincubation with IL-12 increased the surface levels of human leukocyte antigen ( HLA ) class I, HLA class II and intercellular adhesion molecule (ICAM)-1 of those cultures with IL-12Rbeta expression
Walter et al., J Exp Med 2001 (Asthma...) : Initial comparisons indicated that tumor necrosis factor alpha induction of epithelial intercellular adhesion molecule 1 required sequential induction of interleukin (IL)-12 ( p70 ) and interferon gamma, and unexpectedly localized IL-12 production to airway epithelial cells
Yoshida et al., Cell Immunol 2001 : IL-18 in the same concentration range stimulated the production of IL-12, TNF-alpha, and IFN-gamma in culture of PBMC ; however, IL-18 induced expression of ICAM-1 in monocytes was not inhibited by anti-IL-12 , anti-TNF-alpha, or anti-IFN-gamma Ab, suggesting the independence of the upregulating effect of IL-18 on endogenous IL-12, TNF-alpha, and IFN-gamma production ... On the other hand, anti-ICAM-1 and anti-LFA-1 Abs inhibited IL-18 induced production of three cytokines, IL-12 , IFN-gamma, and TNF-alpha, by 60 and 40 %, respectively
Yoshida et al., Naunyn Schmiedebergs Arch Pharmacol 2002 : The effect of IL-12 on ICAM-1 expression on monocytes was marginal even at the highest concentration ( 100 ng/ml ) ... However, in the presence of IL-12 ( 100 ng/ml ), the expression of ICAM-1 induced by IL-18 was significantly enhanced as compared with that obtained by IL-18 alone
Liebau et al., Cytokines Cell Mol Ther 2002 (Osteosarcoma) : ICAM-1 expression on HOS cells was significantly enhanced by IL-12 , but only when co-cultured in cell-to-cell contact with peripheral lymphocytes ... If HOS cells and peripheral lymphocytes were separated in co-cultures, IL-18 could substitute for cell-to-cell contact, facilitating IL-12 mediated enhancement of ICAM-1 ... These findings demonstrate that IL-12 can enhance the expression of ICAM-1 in the presence of IFN-gamma and, with IL-18, enhances NK anti-tumor activity