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CCL2 — IL13

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCL2 → IL13 (increases)
  Evidence: IL-13 increased expression of the proinflammatory cytokines MCP-1 and IL-8 in TNF?? challenged VSMC [105].

Text-mined interactions from Literome

Murao et al., FEBS Lett 1999 : In human vascular endothelial cells, interleukin-1beta and tumor necrosis factor-alpha induced endogenous monocyte chemoattractant protein-1 protein secretion, mRNA expression and promoter activity
Ishikawa et al., J Am Soc Nephrol 1999 : Bioflavonoid quercetin inhibits interleukin-1 induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB
Akoum et al., J Clin Endocrinol Metab 2000 (Endometriosis) : Estradiol amplifies interleukin-1 induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis ... In the present study we report that estradiol ( E2 ) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1 induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid ( mRNA ) synthesis, whereas progesterone had no significant effects
Yoshida et al., Invest Ophthalmol Vis Sci 2001 : IL-4 and -13 , but not IL-10, enhanced constitutive and TNF-alpha induced HRPE IL-8 and MCP-1 secretion ... IL-13 potentiated TNF-alpha induced MCP-1 , but not IL-8 secretion by cocultures
Momoi et al., Chest 2001 (Adenocarcinoma...) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induced endogenous MCP-1 protein secretion and messenger RNA expression
Ikeda et al., J Leukoc Biol 2002 : It is interesting that IL-10 up-regulated, whereas IL-4 and IL-13 down-regulated monocyte chemoattractant protein-1 ( MCP-1 ) production by unstimulated UG3 cells
Nasu et al., Fertil Steril 2003 : The effects of IL-13 and TNF-beta, on the production of IL-6, IL-11, leukemia inhibitory factor (LIF), IL-8, growth regulated oncogene alpha ( GROalpha ), monocyte chemoattractant protein-1 ( MCP-1 ), regulated on activation, T-cell expressed and secreted ( RANTES ), and eotaxin were investigated
Wright et al., J Clin Immunol 2003 (Osteomyelitis...) : We investigated the potential down-regulators of chemokine secretion IL-4, IL-10, IL-13, dexamethasone, and PGE2, IL-10 and IL-13 down-regulate M. tuberculosis induced IL-8, IP-10, RANTES, and MCP-1 secretion from MG-63 cells by between 48 and 94 % ( P < 0.05 ) but do not inhibit chemokine gene transcription
Ma et al., J Immunol 2004 (Inflammation) : C10/CCL6 neutralization also decreased the ability of IL-13 to stimulate the production of monocyte chemoattractant protein-1 , macrophage inflammatory protein-1alpha, MMP-2, MMP-9, and cathepsins-K, -L, and -S and the ability of IL-13 to inhibit alpha1-antitrypsin
Wright et al., Microbes Infect 2004 : In contrast, T ( h ) 2 cytokines increased C-C chemokine secretion from MG-63 osteoblastic cells ( P < 0.05 ), and IL-4 and IL-13 caused similar up-regulation of CCL2 secretion from primary osteoblasts
Elhofy et al., J Leukoc Biol 2005 (Encephalomyelitis, Autoimmune, Experimental) : Overexpression of CCL2 in the CNS resulted in decreased interleukin-12 receptor expression by antigen-specific T cells
Bouchelouche et al., J Urol 2006 : We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and SCF in response to IL-4, IL-13 , IL-1beta and tumor necrosis factor-alpha ... IL-4 and IL-13 given separately stimulated MCP-1 , IL-6 and SCF secretion in a concentration ( 0.01 to 100 ng/ml ) and time ( 0 to 24 hours ) dependent manner
Ip et al., Clin Exp Immunol 2006 (MAP Kinase Signaling System) : Inhibition of p38 MAPK, ERK and JAK-2 activities by pretreating the cells with their corresponding inhibitors SB203580, PD98059 and AG490, respectively, significantly suppressed IL-4- and IL-13 induced MCP-1 production in BEAS-2B cells ... Together, the above results illustrate that the activation of p38 MAPK, ERK and JAK-2 but not JNK is crucial for IL-4- and IL-13 induced MCP-1 release in human bronchial epithelial cells
Gu et al., Am J Physiol Lung Cell Mol Physiol 2010 (Hypersensitivity...) : Intelectin is required for IL-13 induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation ... When IL-13 induced intelectin-1 and -2 expression was inhibited by RNA interference, IL-13 induced extracellular signal regulated kinase 1/2 phosphorylation and MCP-1 and -3 production by MLE12 cells was inhibited ... We conclude that intelectin, a molecule expressed by airway epithelial cells and upregulated in asthma, is required for IL-13 induced MCP-1 and -3 production in mouse lung epithelial cells and contributes to allergic airway inflammation
Zhu et al., Journal of biomedical research 2010 : Recombinant IL-13 inhibited tumor necrosis factor-a (TNF-a), IL-1a, IL-1ß, monocyte chemoattractant protein-1 ( MCP-1 ), IL-8, and transforming growth factor-ß1 ( TGF-ß1 ) mRNA expressions in a dose dependent manner
Burel et al., Nucleic acid therapeutics 2013 : In mice, the alterations at 70 mg/kg/week included spleen weight increase up to 1.4-fold relative to control, increases in alanine aminotransferase and aspartate aminotransferase up to 1.8-fold over control, interleukin-10 increases up to 3.7-fold, and monocyte chemoattractant protein-1 increase up to 1.9-fold over control
Goppelt-Struebe et al., FEBS Lett 1995 : Synergistic induction of monocyte chemoattractant protein-1 ( MCP-1 ) by platelet derived growth factor and interleukin-1
Hayashi et al., J Neuroimmunol 1995 : Lipopolysaccharide (LPS), interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha induced MCP-1 secretion by astrocytes, but not microglia
Colotta et al., Am J Pathol 1994 : Induction of MCP-1 transcript by thrombin was not reduced by blocking interleukin-1 and tumor necrosis factor, suggesting that these mediators are not involved in thrombin induced expression of MCP-1
Yano et al., J Immunol 1996 : Furthermore, human alveolar macrophages produced MCP-1 spontaneously, and the production was inhibited by IL-4 or IL-13 , but was augmented by IL-10
Seitz et al., Eur J Immunol 1996 : In resting and cytokine stimulated MNC, IL-13 markedly inhibited IL-1 beta, IL-8 and monocyte chemoattractant protein-1 ( MCP-1 ) release and potently stimulated interleukin-1 receptor antagonist ( IL-1ra ) synthesis
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Goebeler et al., Immunology 1997 : Interleukin-13 selectively induces monocyte chemoattractant protein-1 synthesis and secretion by human endothelial cells ... Employing in situ hybridization and enzyme linked immunosorbent assay ( ELISA ) techniques we demonstrate that IL-13 , which shares many of its activities with IL-4, selectively induces expression of the C-C chemokine monocyte chemoattractant protein (MCP)-1 in human umbilical vein endothelial cells ( HUVEC ) ... In contrast to the synergistic effect of IL-13 and tumour necrosis factor-alpha (TNF-alpha) on endothelial vascular cell adhesion molecule-1 ( VCAM-1 ) surface expression, TNF-alpha induced secretion of MCP-1 is not augmented by IL-13
Jordan et al., Br J Pharmacol 1997 : IL-13 , but not IL-10, significantly enhanced IL-8 and MCP-1 release in response to IL-1alpha or TNFalpha
Flesch et al., Int Immunol 1998 : IL-13 had no effect on MIP-1alpha, MIP-2 and KC production by infected BMM, but slightly reduced MCP-1 release