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IL17A — PIK3R1
Text-mined interactions from Literome
Cho et al., Immunol Lett 2007
(Arthritis, Rheumatoid) :
Moreover
PI3K/Akt inhibitor, NF-kappaB inhibitor, and FK506 significantly
inhibited IL-15 induced
IL-17 production in CD4+ T cells
Kim et al., J Immunol 2007
(Asthma...) :
Our results also showed that
PI3K inhibitors or AdPTEN down-regulated a transcription factor, NF-kappaB activity, and BAY 11-7085 substantially
reduced the increased levels of
IL-17 after TDI inhalation
Gislette et al., TheScientificWorldJournal 2010
(Neoplasms...) :
IL-17 could
activate Src/PI3K , MAPK, Stat3, and PKC, resulting in carcinogenesis
Harris et al., Eur J Immunol 2012
:
In this study, we reveal a novel
role for
PI3K? in the regulation of the pro-inflammatory cytokine
IL-17 ... Loss of
PI3K? or expression of a catalytically inactive mutant of PI3K? in mice
led to increased
IL-17 production both in vitro and in vivo in response to various stimuli
Roller et al., J Immunol 2012
(Dermatitis...) :
We also show that PI3Kd and
PI3K? inhibitors
reduced IFN-? production by human TCR?d T cells and
IL-17 and IFN-? production by PBMCs from psoriatic or healthy donors
Liu et al., Autophagy 2013
(Pulmonary Fibrosis) :
In
response to
IL17A stimulation,
PI3K was activated and resulted in phosphorylation of GSK3B at Ser9, which subsequently attenuated the interaction of GSK3B with BCL2