◀ Back to EPHB2

EPHB2 — IL17RD

Text-mined interactions from Literome

Torii et al., Dev Cell 2004 (MAP Kinase Signaling System) : Thus, hSef binds to activated forms of MEK, inhibits the dissociation of the MEK-ERK complex, and blocks nuclear translocation of activated ERK ... Downregulation of endogenous hSef by hSef siRNA enhances the stimulus induced ERK nuclear translocation and the activity of Elk-1
Darby et al., Br J Cancer 2009 (Prostatic Neoplasms) : In signalling studies, hSef inhibited FGF induced ERK phosphorylation, migration to the nucleus and activation of a reporter gene
Zhang et al., Gynecol Oncol 2011 (Adenocarcinoma...) : Using luciferase reporter assays and western blot analysis, we detected the effect of hSef on MAPK/ERK mediated FGF2 signaling ... We found that the hSef expression was positively regulated by FGF2 induced MAPK/ERK signaling and inversely, hSef expression efficiently inhibited the activity of FGF2 induced MAPK/ERK signaling, indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells