Gene interactions and pathways from curated databases and text-mining

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IL18 — IL6

Text-mined interactions from Literome

Prinz et al., J Neurochem 1999 : IL-18 inhibits the LPS induced release of IL-12 and attenuates that of TNF-alpha, whereas the production of IL-6 and macrophage inflammatory protein-1alpha is only marginally affected
Shinoda et al., Cell Signal 1999 : C2-ceramide did not affect the IL-6 synthesis induced by interleukin-1
Albanesi et al., J Invest Dermatol 2000 (Dermatitis, Allergic Contact...) : In addition, interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage colony stimulating factor, and interleukin-6 , with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Netea et al., Eur J Immunol 2000 (Disease Models, Animal...) : IL-6 synthesis was also strongly induced by IL-18 and, as revealed by studies in knockout mice, this production was not dependent on interactions between endogenous cytokines of the TNF/TNF receptor family : TNF-alpha, lymphotoxin-alpha, Fas/Fas ligand (L) or CD40/CD40L
Ishikawa et al., Jpn J Vet Res 2001 : Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
Andoh et al., Biochim Biophys Acta 2002 : In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha induced IL-6 secretion through the induction of IL-6 mRNA stabilization
Jablonska et al., Immunol Invest 2002 (Inflammation) : Effect of IL-18 on the release of IL-6 and its soluble receptors : sIL-6Ralpha and sgp130 by human neutrophils
Wheeler et al., J Neurochem 2003 : IL-18 induced intracellular expression of IL-1 alpha and proIL-1 beta, and release of IL-6 from mixed glia
Yamamoto et al., Arthritis Rheum 2003 (Arthritis, Experimental...) : The effects of RasDN overexpression on cellular proliferation, interleukin-1 (IL-1) induced activation of mitogen activated protein kinases ( extracellular signal regulated kinase [ ERK ], p38, c-Jun N-terminal kinase [ JNK ] ), and IL-6 production by synovial cells were analyzed
Planck et al., Invest Ophthalmol Vis Sci 1992 : Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1
Shimizu et al., Arch Oral Biol 1992 : Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells
Nishitai et al., J Biol Chem 2004 : Instead, interleukin-1 beta (IL-1 beta) induced IL-6 gene expression was greatly suppressed in sek1 ( -/- ) mkk7 ( -/- ) fibroblasts
Saito et al., Mech Ageing Dev 2003 (Endotoxemia...) : The stress mediated induction of interleukin-1beta, interleukin-6 , and interleukin-10 ( IL-1beta, IL-6, and IL-10 ) in the circulating blood tended to be higher with aging in both CLP and LPS models, and in particular, the induction of IL-6 was significantly augmented with aging
Silfverswärd et al., J Orthop Res 2004 : Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells
Nesbitt et al., Mol Biol Cell 1992 (Inflammation) : We employed ribonuclease protection assays to measure the expression of IL-6-R and gp130 mRNA in primary rat hepatocytes in response to IL-6, interleukin-1 , dexamethasone, and combinations thereof
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6 , transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Stuyt et al., J Endotoxin Res 2005 (Acute-Phase Reaction...) : IL-18 is a pro-inflammatory cytokine of the IL-1 family and it induces IL-1, TNF, and IL-6 , all of which are endogenous pyrogens
Sekiyama et al., Immunity 2005 : This, together with the observation that IL-6 was not induced in IL-18-deficient mice, showed that IL-6 induction by stress is dependent on IL-18
Takahashi et al., Antimicrob Agents Chemother 2005 : In addition, ciprofloxacin suppressed the interleukin-18 induced production of tumor necrosis factor alpha, gamma interferon, and interleukin-12 in peripheral blood mononuclear cells by inhibiting the expression of intercellular adhesion molecule 1, B7.1, B7.2, and CD40 on monocytes, and this effect could be reversed by the addition of indomethacin or NS398
Chiang et al., Blood Purif 2006 (Uremia) : Plasma interleukin-18 levels in hemodialysis patients : increased by dialysis process and association with interleukin-6 and tumor necrotic factor-alpha
Sekiyama et al., J Med Invest 2005 : This, together with the observation that IL-6 was not induced in stressed-IL-18 deficient mice, showed that IL-6 induction by stress is dependent on IL-18
Krogh-Madsen et al., Am J Physiol Endocrinol Metab 2006 (Insulin Resistance) : We investigated the effects of TNF and IL-6 on IL-18 gene expression in skeletal muscle and adipose tissue
Hashmi et al., Coron Artery Dis 2006 (Angina, Unstable) : Role of interleukin-17 and interleukin-17 induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease
Szabo et al., J Clin Immunol 1991 (Burns...) : Furthermore, interleukin-4 dependent downregulation of monocyte interleukin-6 expression is confirmed at both the supernatant and the mRNA levels
Tucci et al., Ann N Y Acad Sci 2007 (Myositis) : We present evidence that DM and PM are characterized by a predominant Th1 immune response with high production of both interferon (IFN)-gamma and interleukin (IL)-18 in the presence of reduced levels of IL-4 and IL-6
Ho et al., J Leukoc Biol 2007 : We found that IL-33, but not IL-1beta or IL-18 , induced IL-13 and IL-6 production by mouse bone marrow derived, cultured mast cells ( BMCMCs ) independently of IgE ... In BMCMCs incubated with the potently cytokinergic SPE-7 IgE without specific antigen, IL-33, IL-1beta, and IL-18 each promoted IL-13 and IL-6 production, but the effects of IL-33 were more potent than those of IL-1beta or IL-18
Burch et al., Agents Actions 1991 (Wounds and Injuries) : Basal interleukin-1 and 6 release were not affected by sucralfate, but the agent enhanced interleukin-1 stimulated interleukin-6 release from fibroblasts
Kondo et al., Int Immunol 2008 (Hyperplasia...) : Basophils, comprising IL-18Ralpha ( + ) cells ( 14.2 % ) and IL-33Ralpha ( + ) cells ( 34.6 % ), and mast cells, comprising IL-18Ralpha ( + ) cells ( 2.0 % ) and IL-33Ralpha ( + ) cells ( 95.6 % ), produce IL-4, IL-6 , IL-13, granulocyte macrophage colony stimulating factor ( GM-CSF ) and chemokines ( RANTES, MIP-1alpha, MIP-1beta and MCP-1 ), upon stimulation with IL-18 and/or IL-33 in the presence of IL-3
Krogh Rasmussen et al., Acta Endocrinol (Copenh) 1991 : In conclusion, it is unlikely that interleukin 6 by itself mediates the biological effects of interleukin 1 on human thyroid cells
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Baigrie et al., Lymphokine Cytokine Res 1991 (Aortic Aneurysm...) : A sequential interleukin-1 beta and interleukin-6 response has not been noted before in vivo, and would seem to provide evidence supporting the in vitro observation that interleukin-1 induces interleukin-6 synthesis and release
Braquet et al., Int Arch Allergy Appl Immunol 1991 : We compared the effects of platelet activating factor (PAF), interleukin-1 beta (IL-1 beta) and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on IL-6 production by confluent L929 mouse fibroblasts
Nold-Petry et al., J Biol Chem 2009 (MAP Kinase Signaling System) : In addition, we silenced IL-18Ralpha with small interfering RNA in primary human blood cells and observed up to 4-fold increases in the secretion of lipopolysaccharide- and IL-12/IL-18 induced IL-1beta, IL-6 , interferon-gamma, and CD40L
Zhang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010 : [ N-acetylcysteine antagonizes the Interleukin-18 induced expression of TNF-alpha and IL-6 in mouse vascular smooth muscle cells ] ... To explore the effect of N-acetylcysteine ( NAC ) on the interleukin(IL)18 induced expression of tumor necrosis factor (TNF) alpha and interleukin(IL) 6 in mouse vascular smooth muscle cells ( VSMC ) ... IL-18 significantly increased the mRNA expression and protein secretion of TNF-alpha and IL-6 ( P > 0.01 ) in a dose dependent and a time dependent ways ... NAC inhibited the mRNA expression and protein secretion of TNF-alpha and IL-6 induced by IL-18 ( P > 0.01 ) ... N-acetylcysteine antagonizes the production of TNF-alpha and IL-6 induced by IL-18 in VSMC
Zhang et al., Beijing Da Xue Xue Bao 2010 (Chlamydia Infections...) : [ Early production of interleukin-17 in airway upon Chlamydia trachomatis infection increases the local secretion of IL-6 and MIP-2 ]
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : Grape seed proanthocyanidin extract inhibits interleukin-17 induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells
Tanabe et al., Journal of neuroinflammation 2011 : Midazolam suppresses interleukin-1ß induced interleukin-6 release from rat glial cells
Nakamura et al., Eur J Oral Sci 2011 (Gingivitis) : Involvement of angiotensin II type 1 receptors in interleukin-1ß induced interleukin-6 production in human gingival fibroblasts
Zhang et al., Mol Cell Biol 1990 (Chromosome Deletion) : Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence
Libert et al., Eur J Immunol 1990 : Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
Kuroyanagi et al., Biochimie 2013 : ( - ) -Epigallocatechin gallate amplifies interleukin-1 stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells
Bunning et al., Biochem Biophys Res Commun 1990 : Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes
Shalaby et al., Clin Immunol Immunopathol 1989 (Shock, Septic) : Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo
Helle et al., Eur J Immunol 1988 : Interleukin 6 is involved in interleukin 1-induced activities
Zimecki et al., Arch Immunol Ther Exp (Warsz) 1994 : Interleukin 6 produced by activated thymocytes induces interleukin 1 production by macrophages
Cadman et al., Neurosci Lett 1994 (Astrocytoma) : cAMP is not involved in interleukin-1 induced interleukin-6 release from human astrocytoma cells
Carlson et al., J Neurochem 1995 (Astrocytoma) : Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1 induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C ... We conclude that tyrosine kinase activity is essential for interleukin-1 induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved
Zitnik et al., Am J Physiol 1993 : cAMP inhibition of interleukin-1 induced interleukin-6 production by human lung fibroblasts
Adams et al., Neurosurgery 1994 (Neuroma, Acoustic) : Tumor necrosis factor-alpha, interleukin-1-beta , and cholera toxin all stimulated IL-6 secretion
Hoffmann et al., J Hepatol 1994 : Furthermore, lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta and phorbol ester induced interleukin-6 production and, at the same time, suppressed the level of interleukin-6 receptor mRNA
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF, and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Ng et al., J Biol Chem 1994 : Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1
Moutabarrik et al., Scand J Immunol 1994 : IL-6 was detected in the culture supernatants of human GEC and its production was enhanced in time and dose dependent manner by lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta) and tumour necrosis alpha ( TNF-alpha )
Ueo et al., J Am Coll Surg 1994 : The IL-6 secretion by skin explants was significantly enhanced either by tumor necrosis factor or interleukin-1 , while it was inhibited by corticosteroids
Utsunomiya et al., Eur J Pharmacol 1994 (Pleurisy) : However, production of tumor necrosis factor (TNF) and interleukin-1 in the pleural exudate was significantly enhanced by the pretreatment with indomethacin, whereas the interleukin-6 level was reduced
Levine et al., Psychoneuroendocrinology 1994 : Pituitary-adrenal and interleukin-6 responses to recombinant interleukin-1 in neonatal rats
Boxman et al., J Invest Dermatol 1993 : The remaining interleukin-1 activity, however, was sufficient for maximal induction of interleukin-6 production in fibroblasts
de Fijter et al., Am J Kidney Dis 1996 : In addition, interleukin-1-beta induced interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Fc receptor- mediated uptake of S epidermidis by PMO in the complete absence of Ca++ was comparable to that by PMO incubated in GHBSS with calcium
Topley et al., J Am Soc Nephrol 1996 : Similarly, interleukin (IL)-1 beta induced IL-6 synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Meyer et al., Clin Sci (Lond) 1997 (Endotoxemia...) : 3. Administration of endotoxin induced a greater than fourfold increase in brain interleukin-1 , a greater than threefold increase in interleukin-6 and an increase in mRNA for both cytokines
Jones et al., J Pathol 1997 (Meningioma) : Effect of interleukin-1 and dexamethasone on interleukin-6 production and growth in human meningiomas
Porro et al., J Pharmacol Exp Ther 1998 (Shock, Septic) : In vitro experiments showed that ITF1779 inhibited not only huTNFalpha induced cytotoxicity on LM cells but also another response of the same cells, interleukin-1 induced interleukin-6 production
Kozawa et al., Prostaglandins Leukot Essent Fatty Acids 1998 : However, retinoic acid had little effect on the IL-6 synthesis induced by interleukin-1
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2
Shapiro et al., Proc Natl Acad Sci U S A 1998 : Stimulation of U1 cells with IL-18 resulted in increased production of IL-6 , and exogenous IL-6 added to U1 cells increased HIV-1 production 4-fold over control