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CCL5 — IL1B

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCL5 → IL1B (increases) Newton et al., J Pharmacol Exp Ther 2007*
  Evidence: Similar levels of RANTES and MCP-1 release were induced by IL-1 and TNF treatments. However, the induction of IL-6, IL-8, and GMCSF by TNF was 50 to 80% lower than for IL-1, whereas TNF-induced GRO was some 35- to 40-fold lower than that for IL-1. In all instances, preincubation with PS-1145 or ML120B resulted in a significant attenuation of cytokine release (Fig. 6).
• OpenBEL Selventa BEL large corpus: CCL5 → IL1B (increases) Nanki et al., J Immunol 2001*
  Evidence: On the other hand, CCL2, CCL5, and CXCL12 were expressed on RA FLS, and their production was regulated by TNF-alpha, IL-1beta, and TGF-beta1.
• OpenBEL Selventa BEL large corpus: CCL5 → IL1B (increases) Peng et al., J Immunol 2005
  Evidence: IL-1 (1 ng/ml) induced marked release of eotaxin, RANTES, or GM-CSF from human ASM cells when cultured on Pl (Fig. 1)
• OpenBEL Selventa BEL large corpus: CCL5 → IL1B (increases) Hai et al., Curr Drug Discov Technol 2008*
  Evidence: For example, IL-11b stimulates the production of CCL2, eotaxin, IL-6, IL-8, and RANTES in airway smooth muscle cells (Fig. (1)).

Text-mined interactions from Literome

Mustafa et al., Eur J Oral Sci 2001 : IL-1beta ( 3-300 pg/ml ) also enhanced the production of Rantes/CCL5 in gingival fibroblasts ... The amount of Rantes/CCL5 induced by IL-1beta ( 300 pg/ml ), however, was less than that induced by TNFalpha ( 10 ng/ml )
Nanki et al., J Immunol 2001 (Arthritis, Rheumatoid) : On the other hand, CCL2, CCL5 , and CXCL12 were expressed on RA FLS, and their production was regulated by TNF-alpha, IL-1beta , and TGF-beta1
Edwards et al., Am J Respir Cell Mol Biol 2006 : After 1 h pretreatment, combined treatment significantly inhibited rhinovirus 16, 1B, and IL-1beta induced CCL5 and CXCL8 protein and mRNA production in BEAS-2B cells compared with fluticasone alone
Marotte et al., Rheumatology (Oxford) 2010 (Arthritis, Experimental...) : GTE ( 2.5-40 microg/ml ) inhibited IL-1beta induced MCP-1/CCL2 ( 10 ng/ml ), RANTES/CCL5 , GROalpha/CXCL1 and IL-8/CXCL8 production in human RA synovial fibroblasts ( P < 0.05 )