Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

IL1B — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Williams et al., J Immunol 2004 (Disease Susceptibility...) : Inhibition of PI3K resulted in increased serum levels of IL1-beta , IL-2, IL-6, IL-10, IL-12, and TNF-alpha in septic mice
Molnarfi et al., J Immunol 2007 : In contrast, PI3K inhibition increased the production of IL-1beta protein in both CE ( sHUT ) - and LPS activated monocytes, the enhancement being drastically higher in the former
Lin et al., J Cell Physiol 2007 (Lung Neoplasms) : Src, PDGFR, and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta stimulated Src, PDGFR, and Akt phosphorylation, respectively
Wrann et al., J Immunol 2007 (Sepsis) : In addition, PI3K inhibition resulted in strongly elevated TLR-4 mediated generation of IL-1beta and IL-8 in neutrophils when these cells were co-stimulated with C5a
Riera et al., Reproduction 2007 : In summary, results presented herein demonstrate that IL1beta stimulates PI3K/PKB- , P70S6K-, and ERK1/2 dependent pathways in rat Sertoli cells
Tanabe et al., J Periodontal Res 2008 : Phosphatidylinositol-3'-kinase inhibitors added during the tolerance-induction period markedly attenuated the increase in interleukin-1 beta secretion but had no effect on tumor necrosis factor-alpha
Cheung et al., J Immunol 2008 (AIDS Dementia Complex) : Using pharmacological inhibitors and small interfering RNA gene knockdown, we demonstrated that concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120 induced IL-1beta production
Kuijk et al., Blood 2008 (Mevalonate Kinase Deficiency) : Here we show that inhibition of HMG-CoA reductase by simvastatin treatment, mimicking MKD, results in increased IL-1beta secretion in a Rac1/PI3K dependent manner
Tamizhselvi et al., J Pharmacol Exp Ther 2009 : The PI3K inhibitor LY294002 [ 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ] abolished the H ( 2 ) S-mediated activation of AKT and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein treated acinar cells
Yamamura et al., Int Arch Allergy Immunol 2009 : Eotaxin induced production of IL-1beta , IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002