◀ Back to PIK3R1
IL1B — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL1-mediated signaling events:
IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP)
→
IL1 beta fragment/IL1R1/IL1RAP/PI3K complex (IL1B-IL1R1-IL1RAP-PIK3CA-PIK3R1)
(modification, collaborate)
Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL1 beta fragment/IL1R1/IL1RAP/PI3K complex (IL1B-IL1R1-IL1RAP-PIK3CA-PIK3R1)
(modification, collaborate)
Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
RelA (RELA)
→
IL1 beta fragment/IL1R1/IL1RAP/PI3K complex (IL1B-IL1R1-IL1RAP-PIK3CA-PIK3R1)
(modification, collaborate)
Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
NF kappa B1 p50 (NFKB1)
→
IL1 beta fragment/IL1R1/IL1RAP/PI3K complex (IL1B-IL1R1-IL1RAP-PIK3CA-PIK3R1)
(modification, collaborate)
Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction
Text-mined interactions from Literome
Williams et al., J Immunol 2004
(Disease Susceptibility...) :
Inhibition of
PI3K resulted in increased serum levels of
IL1-beta , IL-2, IL-6, IL-10, IL-12, and TNF-alpha in septic mice
Molnarfi et al., J Immunol 2007
:
In contrast,
PI3K inhibition
increased the production of
IL-1beta protein in both CE ( sHUT ) - and LPS activated monocytes, the enhancement being drastically higher in the former
Lin et al., J Cell Physiol 2007
(Lung Neoplasms) :
Src, PDGFR, and
PI3K/Akt mediated the effects of
IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta stimulated Src, PDGFR, and Akt phosphorylation, respectively
Wrann et al., J Immunol 2007
(Sepsis) :
In addition,
PI3K inhibition
resulted in strongly elevated TLR-4 mediated generation of
IL-1beta and IL-8 in neutrophils when these cells were co-stimulated with C5a
Riera et al., Reproduction 2007
:
In summary, results presented herein demonstrate that
IL1beta stimulates
PI3K/PKB- , P70S6K-, and ERK1/2 dependent pathways in rat Sertoli cells
Tanabe et al., J Periodontal Res 2008
:
Phosphatidylinositol-3'-kinase inhibitors added during the tolerance-induction period markedly
attenuated the increase in
interleukin-1 beta secretion but had no effect on tumor necrosis factor-alpha
Cheung et al., J Immunol 2008
(AIDS Dementia Complex) :
Using pharmacological inhibitors and small interfering RNA gene knockdown, we demonstrated that concomitant activation of Lyn, Pyk2, and class IA
PI3K are
required for gp120 induced
IL-1beta production
Kuijk et al., Blood 2008
(Mevalonate Kinase Deficiency) :
Here we show that inhibition of HMG-CoA reductase by simvastatin treatment, mimicking MKD, results in increased
IL-1beta secretion in a
Rac1/PI3K dependent manner
Tamizhselvi et al., J Pharmacol Exp Ther 2009
:
The
PI3K inhibitor LY294002 [ 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ] abolished the H ( 2 ) S-mediated activation of AKT and
increases tumor necrosis factor alpha and
interleukin 1beta levels in caerulein treated acinar cells
Yamamura et al., Int Arch Allergy Immunol 2009
:
Eotaxin induced production of
IL-1beta , IL-6, and MIP-1beta was significantly
reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or
PI3K inhibitor LY294002