Gene interactions and pathways from curated databases and text-mining

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IL1RN — PIK3R1

Text-mined interactions from Literome

O'Connor et al., J Immunol 2007 (Diabetes Mellitus, Type 2) : Inhibition of PI3K with wortmannin or blockage of IRS-2/PI3K complex formation with a cell permeable IRS-2 derived tyrosine phosphopeptide inhibited IL-4 dependent IL-1RA production in db/+ macrophages
Corbett et al., J Immunol 2012 (Neurodegenerative Diseases) : Activation of type IA p110a PI3K and Akt by gem and abrogation of gem induced upregulation of IL-1Ra by inhibitors of PI3K and Akt indicate a role of the PI3K-Akt pathway in the upregulation of IL-1Ra