Gene interactions and pathways from curated databases and text-mining

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IL3 — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Craddock et al., J Biol Chem 1999 : Using regulated expression of dominant negative p85 ( Deltap85 ) in stably transfected IL-3 dependent BaF/3 cells, we have specifically investigated the role of class IA PI3K in IL-3 signaling
VilariƱo et al., J Immunol 2005 : The kinetics, dose response, and pharmacologic characteristics of the IL-3 priming of stimulus induced Erk phosphorylation support the involvement of a yet unknown mechanism that is independent of IL-3 induced Erk and PI3K activation
Maurer et al., Mol Cell 2006 : S159 phosphorylation of MCL-1 was induced by IL-3 withdrawal or PI3K inhibition and prevented by AKT or inhibition of GSK-3, and it led to increased ubiquitinylation and degradation of MCL-1
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Scheid et al., Proc Natl Acad Sci U S A 1998 : Interleukin 3 (IL-3) , on the other hand, requires PI3K for survival, and blocking PI3K partially inhibited Bad phosphorylation
Bavelloni et al., J Cell Sci 1999 (Osteosarcoma) : Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells