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IL4 — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Jiang et al., J Immunol 2001, Wurster et al., Mol Cell Biol 2002, Sun et al., Nature 1995, Izuhara et al., Blood 1996
Evidence: mutant phenotype, assay, physical interaction, other species
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NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: assay, physical interaction, other species
Text-mined interactions from Literome
Ceponis et al., J Biol Chem 2000
:
In contrast, although the
PI3K inhibitors wortmannin and LY294002 did not
affect IL-4 or IL-13 STAT 6 activation, they significantly inhibited the ability of either cytokine to lower TER
Frossi et al., J Immunol 2007
:
Selective activation of
Fyn/PI3K and p38 MAPK
regulates IL-4 production in BMMC under nontoxic stress condition
O'Connor et al., J Immunol 2007
(Diabetes Mellitus, Type 2) :
Examination of IL-4 signaling in db/db macrophages revealed that
IL-4 dependent
IRS-2/PI3K complex formation and IRS-2 tyrosine phosphorylation was reduced compared with db/+ macrophages ... These results indicate that in the db/db mouse model of T2D, macrophage expression of SOCS-3 is increased, and impaired
IL-4 dependent
IRS-2/PI3K formation induces a state of IL-4 resistance that disrupts IL-4 dependent production of IL-1RA
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Xia et al., Mol Cell Biochem 2012
(Asthma...) :
We investigated the
effects of
PI3K inhibitor wortmannin on iNOS expression in bronchiole epithelial cells and NO,
IL-4 and IFN-? levels in lung tissues of asthmatic rat model, which was prepared by 10 % OVA solution sensitization and 1 % OVA aerosol challenge
Bavelloni et al., J Cell Sci 1999
(Osteosarcoma) :
Phosphatidylinositol 3-kinase translocation to the nucleus is
induced by
interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells