Gene interactions and pathways from curated databases and text-mining

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IL5 — PAF1

Text-mined interactions from Literome

Urasaki et al., J Leukoc Biol 2001 : These findings suggest that IL-5 activates both cPLA2 and 5-LO but PAF activates only 5-LO
Kushikata et al., Neurosci Lett 2006 (Fever) : PAF and its receptor are found in brain and PAF affects or is affected by the production of sleep promoting cytokines such as interleukin-1
Wang et al., Mediators Inflamm 1996 : Our previous studies have shown that EsA could reduce the release of platelet activating factor (PAF) from rat macrophages, and inhibit interleukin-1 and interleukin-6 production from routine macrophages
Bussolino et al., Biochim Biophys Acta 1987 : These findings indicate that interleukin 1 induces the PAF synthesis by a deacylation/reacetylation mechanism into human endothelial cells
Okada et al., Am J Respir Cell Mol Biol 1997 : Release of MMP-9 by eosinophils was increased by IL-5 , PAF, or both, but the substrate degrading activity of MMP-9 was increased only in the presence of both IL-5 and PAF , indicating that the releasing and activating mechanisms of MMP-9 are involved in eosinophil basement membrane migration