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IL6 — PIK3R1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Birkenkamp et al., Exp Hematol 2000
(Acute Disease...) :
An inhibitor of
PI3-K differentially
affects proliferation and
IL-6 protein secretion in normal and leukemic myeloid cells depending on the stage of differentiation
Tu et al., Cancer Res 2000
(MAP Kinase Signaling System...) :
However,
IL-6 successfully
activated PI 3-K in AF-10 MM cells and IL-6 dependent MH.60 plasmacytoma/hybridoma cells ... IGF-I also successfully activated
PI 3-K in four of four MM patient specimens, and
IL-6 activated PI 3-K in three of four specimens
Kuo et al., Oncogene 2001
:
Our previous works have demonstrated that both
PI 3-K/Akt and STAT3 pathways were concomitantly activated and cooperatively
mediated the anti-apoptotic effect of
IL-6
Hideshima et al., Oncogene 2001
(MAP Kinase Signaling System...) :
We demonstrate that Dex induced apoptosis in MM.1S cells is mediated by downstream activation of caspase-9, with resultant caspase-3 cleavage ; and conversely, that
IL-6 triggers activation of
PI3-K and its association with SHP2, inactivates caspase-9, and protects against Dex induced apoptosis ... Finally, we show that
IL-6 triggered
PI3-K/Akt signaling in MM.1S cells inactivates forkhead transcriptional factor (FKHR), with related G1/S phase transition, whereas LY294002 blocks this signaling, resulting in upregulation of p27 ( KIP1 ) and G1 growth arrest
Williams et al., J Immunol 2004
(Disease Susceptibility...) :
Inhibition of
PI3K resulted in increased serum levels of IL1-beta, IL-2,
IL-6 , IL-10, IL-12, and TNF-alpha in septic mice
Xie et al., Prostate 2004
(Disease Progression...) :
Regulation of
interleukin-6 mediated
PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells ... Addition of androgen blocks
IL-6 mediated
PI3K activation and NE differentiation in LNCaP cells ... In addition, androgen treatment enhances the interaction between AR and gp130, interrupts the
IL-6 induced gp130 mediated
PI3K activation, which may lead to inhibition of IL-6 mediated NE differentiation in LNCaP cells
Chaudhary et al., Toxicology 2004
:
Pharmacological inhibition of phosphatidylinositol 3' kinase (PI3'K) by wortmannin and p38 mitogen activated protein kinase ( MAPK ) by SB203580 reveal that
PI3'K mediates Be-specific p45 phosphorylation and
IL6 release, whereas p38 MAPK regulates the release of IL6 and IL10 and the phosphorylation of p45 independent of metal-salt treatment
Nagel et al., Leukemia 2005
(Hodgkin Disease) :
HLXB9 activates
IL6 in Hodgkin lymphoma cell lines and is
regulated by
PI3K signalling involving E2F3
Yin et al., J Mol Cell Cardiol 2006
:
Isoproterenol induced secretion of
IL-6 was mainly mediated by Gs-AC-cAMP signaling cascade and could be negatively
regulated by Gi and
PI3K
Ganesan et al., Blood 2006
(Inflammation) :
Interestingly, whereas
IL-6 production
required activation of both
PI3K and Ras/Erk pathways, IL-1beta production was dependent only on Ras/Erk activation, suggesting that SHIP may also regulate the Ras/Erk pathway in macrophages ... Inhibition of Ras/Erk or
PI3K suppressed the enhanced production of
IL-6 in SHIP-deficient macrophages
Hanai et al., J Cell Biochem 2006
:
Taken together, these results strongly suggest that
PI3K/Akt negatively
regulates the PDGF-BB stimulated
IL-6 synthesis in osteoblasts
Smyth et al., J Immunol 2006
(Inflammation) :
Furthermore, inhibition of
PI3K by use of LY294002
reduces expression of
IL-6 at both the mRNA and protein level in murine fibroblasts, and we suggest that PI3K is required for activation of PKCdelta
Tang et al., J Immunol 2007
:
Leptin mediated
IL-6 production was
attenuated by OBRl receptor antisense oligonucleotide,
PI3K inhibitor ( Ly294002 and wortmannin ), Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), IkappaB protease inhibitor ( L-1-tosylamido-2-phenylenylethyl chloromethyl ketone ), IkappaBalpha phosphorylation inhibitor ( Bay 117082 ), or NF-kappaB inhibitor peptide
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Kang et al., Eur J Pharmacol 2008
:
In contrast, a JNK 1/2 inhibitor ( SP600125 ) and
PI3K inhibitor ( wortmannin or LY294002 ) did not
block the induction of
IL-6 production by LPS
Suh et al., J Cell Physiol 2009
:
In addition,
IL-6 increased EGFR/src/FAK,
PI3K/Akt phosphorylation and 2-DG uptake as well as GLUT-2 protein expression, which were blocked by AG 1478 ( EGF receptor inhibitor ), PP2 ( src family of tyrosine kinase inhibitor ), PI3K-specific siRNA, and a Akt inhibitor
Liu et al., Horm Metab Res 2009
:
In summary, these results suggest that visfatin induced MCP-1 and
IL-6 production
involve p38 MAPK,
PI3K , and ERK 1/2 pathways in human umbilical vein endothelial cells as determined by inhibition with specific inhibitors
Yang et al., Microvasc Res 2009
(AIDS Dementia Complex) :
Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase
(PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly
diminished IL-8-,
IL-6- , and gp120 induced monocyte adhesion and migration across in vitro BBB models
Sly et al., Blood 2009
(Hypothermia) :
Intriguingly, we found, using isoform-specific
PI3K inhibitors, that LPS- or cytosine-phosphate-guanosine induced
interleukin-6 (IL-6) is positively
regulated by p110alpha, -gamma, and -delta but negatively regulated by p110beta
Yamamura et al., Int Arch Allergy Immunol 2009
:
Eotaxin induced production of IL-1beta,
IL-6 , and MIP-1beta was significantly
reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or
PI3K inhibitor LY294002
Westra et al., Ann N Y Acad Sci 2009
(Arthritis, Rheumatoid) :
Protein and mRNA expression of HIF-1alpha and the
effects of inhibitors of the CaMKII-,
PI3K- , and ERK pathway on VEGF and
IL-6 production were analyzed
Huang et al., Mediators Inflamm 2009
(MAP Kinase Signaling System) :
Upregulation of Salmonella induced
IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor : involvement of
PI3K , p38 MAPK, ERK, JNK, and NF-kappaB
Wang et al., Am J Physiol Cell Physiol 2010
:
Simultaneous inhibition of PKA and
PI3K reduces
IL-6 expression in stimulated chondrocytes well below the basal levels of untreated cells
Liu et al., Neurotox Res 2011
:
These results suggest that
IL-6 protects neurons against NMDA induced apoptosis, and that the IL-6 neuroprotection is jointly
mediated by JAK-STAT3 and
PI3K-Akt signaling pathways
Medina et al., J Immunol 2010
(Inflammation...) :
In this study, we demonstrate that the induction of TNF and
IL-6 expression by LVS in mouse bone marrow derived macrophages was markedly
enhanced when
PI3K activity was inhibited by either of the well-known chemical inhibitors, wortmannin or LY294002
Eda et al., Cell Biol Int 2011
(Arthritis, Rheumatoid) :
The aim of this study is to investigate whether
PI3K ( phosphatidylinositol-3-kinase ) is
involved in IL-1ß ( interleukin-1ß ) -induced
IL-6 production in A549 ( human lung adenocarcinoma epithelial cell ) and human RASF ( rheumatoid arthritis synovial fibroblast ) ...
PI3K inhibitor, LY294002 significantly
reduced IL-1ß induced
IL-6 production in A549 cells but not in RASF, indicating that IL-1ß induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF ... These results indicate that IL-1ß induced
IL-6 production in A549 cells is
mediated by both
PI3K and IRAK4 and suggest that involvement of PI3K in the IL-1 induced IL-6 production is cell type specific
Kim et al., Immune network 2011
:
Both TNF-a and
IL-6 production by HBHA was
regulated by the NF-?B,
PI3-K , and MAPK pathways
Fahmi et al., Cell Signal 2013
(Hypertrophy...) :
Both LIF and
IL-6 [ in the absence of soluble IL-6 receptor ( sIL-6Ra ) ]
activated Erk1/2, JNK1/2, p38-MAPK and
PI3K signalling peaking at 20min and induced cytoprotection against simulated ischemia-reperfusion injury which was blocked by the MEK1/2 inhibitor PD98059 but not the p38-MAPK inhibitor SB203580 ... In conclusion, IL-6 can signal in cardiomyocytes independent of sIL-6R and STAT1/3 and furthermore, that Erk1/2 and
PI3K activation by
IL-6 are both necessary and sufficient for induced cardioprotection
Bavelloni et al., J Cell Sci 1999
(Osteosarcoma) :
Phosphatidylinositol 3-kinase translocation to the nucleus is
induced by
interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells