Gene interactions and pathways from curated databases and text-mining

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IL6 — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Birkenkamp et al., Exp Hematol 2000 (Acute Disease...) : An inhibitor of PI3-K differentially affects proliferation and IL-6 protein secretion in normal and leukemic myeloid cells depending on the stage of differentiation
Tu et al., Cancer Res 2000 (MAP Kinase Signaling System...) : However, IL-6 successfully activated PI 3-K in AF-10 MM cells and IL-6 dependent MH.60 plasmacytoma/hybridoma cells ... IGF-I also successfully activated PI 3-K in four of four MM patient specimens, and IL-6 activated PI 3-K in three of four specimens
Kuo et al., Oncogene 2001 : Our previous works have demonstrated that both PI 3-K/Akt and STAT3 pathways were concomitantly activated and cooperatively mediated the anti-apoptotic effect of IL-6
Hideshima et al., Oncogene 2001 (MAP Kinase Signaling System...) : We demonstrate that Dex induced apoptosis in MM.1S cells is mediated by downstream activation of caspase-9, with resultant caspase-3 cleavage ; and conversely, that IL-6 triggers activation of PI3-K and its association with SHP2, inactivates caspase-9, and protects against Dex induced apoptosis ... Finally, we show that IL-6 triggered PI3-K/Akt signaling in MM.1S cells inactivates forkhead transcriptional factor (FKHR), with related G1/S phase transition, whereas LY294002 blocks this signaling, resulting in upregulation of p27 ( KIP1 ) and G1 growth arrest
Williams et al., J Immunol 2004 (Disease Susceptibility...) : Inhibition of PI3K resulted in increased serum levels of IL1-beta, IL-2, IL-6 , IL-10, IL-12, and TNF-alpha in septic mice
Xie et al., Prostate 2004 (Disease Progression...) : Regulation of interleukin-6 mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells ... Addition of androgen blocks IL-6 mediated PI3K activation and NE differentiation in LNCaP cells ... In addition, androgen treatment enhances the interaction between AR and gp130, interrupts the IL-6 induced gp130 mediated PI3K activation, which may lead to inhibition of IL-6 mediated NE differentiation in LNCaP cells
Chaudhary et al., Toxicology 2004 : Pharmacological inhibition of phosphatidylinositol 3' kinase (PI3'K) by wortmannin and p38 mitogen activated protein kinase ( MAPK ) by SB203580 reveal that PI3'K mediates Be-specific p45 phosphorylation and IL6 release, whereas p38 MAPK regulates the release of IL6 and IL10 and the phosphorylation of p45 independent of metal-salt treatment
Nagel et al., Leukemia 2005 (Hodgkin Disease) : HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3
Yin et al., J Mol Cell Cardiol 2006 : Isoproterenol induced secretion of IL-6 was mainly mediated by Gs-AC-cAMP signaling cascade and could be negatively regulated by Gi and PI3K
Ganesan et al., Blood 2006 (Inflammation) : Interestingly, whereas IL-6 production required activation of both PI3K and Ras/Erk pathways, IL-1beta production was dependent only on Ras/Erk activation, suggesting that SHIP may also regulate the Ras/Erk pathway in macrophages ... Inhibition of Ras/Erk or PI3K suppressed the enhanced production of IL-6 in SHIP-deficient macrophages
Hanai et al., J Cell Biochem 2006 : Taken together, these results strongly suggest that PI3K/Akt negatively regulates the PDGF-BB stimulated IL-6 synthesis in osteoblasts
Smyth et al., J Immunol 2006 (Inflammation) : Furthermore, inhibition of PI3K by use of LY294002 reduces expression of IL-6 at both the mRNA and protein level in murine fibroblasts, and we suggest that PI3K is required for activation of PKCdelta
Tang et al., J Immunol 2007 : Leptin mediated IL-6 production was attenuated by OBRl receptor antisense oligonucleotide, PI3K inhibitor ( Ly294002 and wortmannin ), Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), IkappaB protease inhibitor ( L-1-tosylamido-2-phenylenylethyl chloromethyl ketone ), IkappaBalpha phosphorylation inhibitor ( Bay 117082 ), or NF-kappaB inhibitor peptide
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Kang et al., Eur J Pharmacol 2008 : In contrast, a JNK 1/2 inhibitor ( SP600125 ) and PI3K inhibitor ( wortmannin or LY294002 ) did not block the induction of IL-6 production by LPS
Suh et al., J Cell Physiol 2009 : In addition, IL-6 increased EGFR/src/FAK, PI3K/Akt phosphorylation and 2-DG uptake as well as GLUT-2 protein expression, which were blocked by AG 1478 ( EGF receptor inhibitor ), PP2 ( src family of tyrosine kinase inhibitor ), PI3K-specific siRNA, and a Akt inhibitor
Liu et al., Horm Metab Res 2009 : In summary, these results suggest that visfatin induced MCP-1 and IL-6 production involve p38 MAPK, PI3K , and ERK 1/2 pathways in human umbilical vein endothelial cells as determined by inhibition with specific inhibitors
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8-, IL-6- , and gp120 induced monocyte adhesion and migration across in vitro BBB models
Sly et al., Blood 2009 (Hypothermia) : Intriguingly, we found, using isoform-specific PI3K inhibitors, that LPS- or cytosine-phosphate-guanosine induced interleukin-6 (IL-6) is positively regulated by p110alpha, -gamma, and -delta but negatively regulated by p110beta
Yamamura et al., Int Arch Allergy Immunol 2009 : Eotaxin induced production of IL-1beta, IL-6 , and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002
Westra et al., Ann N Y Acad Sci 2009 (Arthritis, Rheumatoid) : Protein and mRNA expression of HIF-1alpha and the effects of inhibitors of the CaMKII-, PI3K- , and ERK pathway on VEGF and IL-6 production were analyzed
Huang et al., Mediators Inflamm 2009 (MAP Kinase Signaling System) : Upregulation of Salmonella induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor : involvement of PI3K , p38 MAPK, ERK, JNK, and NF-kappaB
Wang et al., Am J Physiol Cell Physiol 2010 : Simultaneous inhibition of PKA and PI3K reduces IL-6 expression in stimulated chondrocytes well below the basal levels of untreated cells
Liu et al., Neurotox Res 2011 : These results suggest that IL-6 protects neurons against NMDA induced apoptosis, and that the IL-6 neuroprotection is jointly mediated by JAK-STAT3 and PI3K-Akt signaling pathways
Medina et al., J Immunol 2010 (Inflammation...) : In this study, we demonstrate that the induction of TNF and IL-6 expression by LVS in mouse bone marrow derived macrophages was markedly enhanced when PI3K activity was inhibited by either of the well-known chemical inhibitors, wortmannin or LY294002
Eda et al., Cell Biol Int 2011 (Arthritis, Rheumatoid) : The aim of this study is to investigate whether PI3K ( phosphatidylinositol-3-kinase ) is involved in IL-1ß ( interleukin-1ß ) -induced IL-6 production in A549 ( human lung adenocarcinoma epithelial cell ) and human RASF ( rheumatoid arthritis synovial fibroblast ) ... PI3K inhibitor, LY294002 significantly reduced IL-1ß induced IL-6 production in A549 cells but not in RASF, indicating that IL-1ß induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF ... These results indicate that IL-1ß induced IL-6 production in A549 cells is mediated by both PI3K and IRAK4 and suggest that involvement of PI3K in the IL-1 induced IL-6 production is cell type specific
Kim et al., Immune network 2011 : Both TNF-a and IL-6 production by HBHA was regulated by the NF-?B, PI3-K , and MAPK pathways
Fahmi et al., Cell Signal 2013 (Hypertrophy...) : Both LIF and IL-6 [ in the absence of soluble IL-6 receptor ( sIL-6Ra ) ] activated Erk1/2, JNK1/2, p38-MAPK and PI3K signalling peaking at 20min and induced cytoprotection against simulated ischemia-reperfusion injury which was blocked by the MEK1/2 inhibitor PD98059 but not the p38-MAPK inhibitor SB203580 ... In conclusion, IL-6 can signal in cardiomyocytes independent of sIL-6R and STAT1/3 and furthermore, that Erk1/2 and PI3K activation by IL-6 are both necessary and sufficient for induced cardioprotection
Bavelloni et al., J Cell Sci 1999 (Osteosarcoma) : Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells