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IL8 — PRKAG1
Text-mined interactions from Literome
Giri et al., J Neurosci 2004
(Inflammation) :
A pharmacological activator of
AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR )
inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha,
interleukin-1beta , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Tang et al., Free Radic Biol Med 2011
(Pneumonia) :
Inhibition of NADPH oxidase activation by apocynin or siRNA targeting p47(phox) ( a subunit of NADPH oxidase ) attenuated the increased intracellular ROS level,
AMPK activation, and
IL-8 induction ... Removal of intracellular ROS by N-acetylcysteine reduced the
AMPK activation and
IL-8 induction
Fitzgerald et al., PloS one 2012
(Carcinoma, Renal Cell...) :
Finally, we have characterized that enhanced levels of IL-6 and IL-8 result in RCC cell invasion and that activation of
AMPK reduces Nox4 expression, IL-6 and
IL-8 production, and RCC cell invasion