Gene interactions and pathways from curated databases and text-mining

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ILK — PIK3R1

Pathways - manually collected, often from reviews:

  • KEGG Focal adhesion: PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 → ILK (protein-protein, compound)
  • KEGG Endometrial cancer: PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 → ILK (protein-protein, compound)

Text-mined interactions from Literome

Stevens et al., Journal of thrombosis and haemostasis : JTH 2004 : Furthermore, ILK activity is dually regulated by PI3K and PKC in thrombin stimulated platelets and regulated by PI3K in collagen stimulated cells
Saito et al., Stroke 2004 (Brain Ischemia) : We administered the PI3-K inhibitor, LY294002, into mouse brains after tFCI and examined the role of PI3-K in the ILK pathway and expression of the ILK/Akt complex by immunohistochemistry, Western blot analysis, and coimmunoprecipitation
Yau et al., Cancer Res 2005 (Neovascularization, Pathologic...) : Inhibition of integrin linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR , Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine induced apoptosis in human orthotopic primary pancreatic cancer xenografts
Liu et al., Clin Chim Acta 2007 : Role of ERK1/2 and PI3-K in the regulation of CTGF induced ILK expression in HK-2 cells ... Chemical inhibitors were used to assess the role of MEK/ERK1/2, PI3-K , and P38 MAPK signaling pathways in induction of ILK by CTGF ... CTGF induced ILK expression was partially reduced by inhibiting ERK1/2 and PI3-K activation
Wu et al., Am J Nephrol 2010 : LXA ( 4 ) inhibited the expression and activity of ILK and activation of Ras, ERK1/2, PI3-K and Akt in HK-2 cells stimulated by CTGF