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ILK — PIK3R1
Pathways - manually collected, often from reviews:
-
KEGG Focal adhesion:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
ILK
(protein-protein, compound)
-
KEGG Endometrial cancer:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
ILK
(protein-protein, compound)
Text-mined interactions from Literome
Stevens et al., Journal of thrombosis and haemostasis : JTH 2004
:
Furthermore,
ILK activity is dually
regulated by
PI3K and PKC in thrombin stimulated platelets and regulated by PI3K in collagen stimulated cells
Saito et al., Stroke 2004
(Brain Ischemia) :
We administered the PI3-K inhibitor, LY294002, into mouse brains after tFCI and examined the
role of
PI3-K in the ILK pathway and expression of the
ILK/Akt complex by immunohistochemistry, Western blot analysis, and coimmunoprecipitation
Yau et al., Cancer Res 2005
(Neovascularization, Pathologic...) :
Inhibition of
integrin linked kinase by a selective small molecule inhibitor, QLT0254,
inhibits the
PI3K/PKB/mTOR , Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine induced apoptosis in human orthotopic primary pancreatic cancer xenografts
Liu et al., Clin Chim Acta 2007
:
Role of ERK1/2 and
PI3-K in the regulation of CTGF induced
ILK expression in HK-2 cells ... Chemical inhibitors were used to assess the
role of MEK/ERK1/2,
PI3-K , and P38 MAPK signaling pathways in induction of
ILK by CTGF ... CTGF induced
ILK expression was partially
reduced by inhibiting ERK1/2 and
PI3-K activation
Wu et al., Am J Nephrol 2010
:
LXA ( 4 ) inhibited the expression and activity of
ILK and
activation of Ras, ERK1/2,
PI3-K and Akt in HK-2 cells stimulated by CTGF