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IL1B — INS

Text-mined interactions from Literome

Laychock et al., Biochem Pharmacol 1998 (Insulinoma...) : Interleukin-1 beta (IL-1 beta) inhibited glucose stimulated insulin release in cultured islets, but the presence of EA, EA-A, and to a lesser extent EA-S, preserved the secretory response
Hao et al., Autoimmunity 1999 (Diabetes Mellitus, Type 1) : We found that ( 1 ) IL-1beta at 10 U/ml increased nitrite production, inhibited insulin release, increased HSP-70 expression and decreased GAD-65 expression ... ( 3 ) In combination, AG completely blocked IL-1beta increased nitrite production, reversed IL-1beta inhibited insulin release by approximately 50 %, completely reversed IL-1beta increased HSP-70 expression, but did not reverse IL-1beta inhibited GAD-65 expression
Giannoukakis et al., Diabetes 1999 : In particular, IL-1beta can impair glucose stimulated insulin production in beta-cells in vitro and can sensitize them to Fas ( CD95 ) /FasL triggered apoptosis ... We demonstrate that adenoviral gene delivery of the cDNA encoding the interleukin-1 receptor antagonist protein ( IL-1Ra ) to cultured islets results in protection of human islets in vitro against IL-1beta induced nitric oxide formation, impairment in glucose stimulated insulin production, and Fas triggered apoptosis activation
Tran et al., J Biol Chem 1999 : By using two cell lines ( HIT-T15 and betaHC13 ) as well as Wistar rat isolated pancreatic islets, we examined the ability of two COX-2-specific antagonists, NS-398 and SC-236, to prevent IL-1beta inhibition of insulin secretion
Hong et al., Eur Cytokine Netw 2000 (Diabetes Mellitus, Type 1) : Although IL-12 induces IL-18R expression in Th1 and B lymphocytes, 24-hours rmIL-12 preincubation neither sensitized islets to effects of 10 nM of rm or rrIL-18 alone nor primed the islets to IL-1 beta actions on insulin release and NO production
Chen et al., Endocrinology 2000 : The early induction of PLD1 probably contributes to the early stimulatory effects of IL-1beta on islet insulin release
Dupraz et al., J Biol Chem 2000 : The decrease in glucose stimulated insulin secretion induced by IL-1beta and IFN-gamma was however not prevented
Andersson et al., Biochem Biophys Res Commun 2001 : Both IL-1 beta and ( IL-1 beta + IFN-gamma ) impaired glucose stimulated insulin release and reduced the insulin content of wt islets, while ( IL-1 beta + IFN-gamma ) reduced glucose oxidation rates and cell viability ... Our data suggest that IL-1 beta may inhibit glucose stimulated insulin release by pathways that are not NO-dependent and not related to glucose metabolism or cell death
Han et al., Diabetes 2001 : We also evaluated the effect of TIMP-1 on IL-1beta induced inhibition of glucose stimulated insulin secretion ( GSIS ) in freshly isolated rat pancreatic islets
Sprinkel et al., Eur Cytokine Netw 2001 : Glucose has been shown to modulate the effects of IL-1 beta on accumulated insulin release and potentiate NO production in rat islets, but the biochemical mechanism is unknown
Mabley et al., Br J Pharmacol 2001 (Diabetes Mellitus, Experimental) : In vitro the cytokine combination ; interleukin-1beta , tumor necrosis factor-alpha and interferon-gamma inhibited glucose stimulated insulin secretion from isolated rat islets of Langerhans and decreased RIN-5F cell viability
Wu et al., J Surg Res 2001 : We tested the in vitro effects of interleukin (IL)-1 beta , tumor necrosis factor (TNF)alpha, and interferon (IFN)gamma on glucose stimulated insulin release in the MIN6 beta-cell line and correlated metabolic dysfunction with NO production and rates of apoptosis
Jeong et al., Exp Mol Med 2002 (Diabetes Mellitus, Type 1) : The stimulatory effect of IL-1beta on the insulin secretion of rat pancreatic islet is not related with iNOS pathway ... The stimulatory effect of IL-1beta on the insulin secretion of rat islets was not prevented by NMMA ... These results suggested that the stimulatory effect of IL-1beta on the insulin secretion of rat islets is independent of iNOS related NO production of IL-1beta and the enzyme activity of nitric oxide synthase
Chen et al., Endocrinology 2002 : Lisofylline ( LSF ), an anti-inflammatory agent, has been shown to protect pancreatic islets from IL-1 beta induced inhibitory effects on insulin release
Stickings et al., Cytokine 2002 (Insulinoma...) : Interleukin-1beta induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin ... Interleukin (IL)-1 beta induced inhibition of glucose stimulated insulin secretion in rat islets of Langerhans is mediated in part by nitric oxide ( NO ) ... Using rat islets and the beta cell line BRIN-BD11, we have investigated whether synthesis of BH ( 4 ) limits IL-1beta induced NO generation and inhibition of glucose induced insulin secretion ... DAHP reversed IL-1 beta induced inhibition of islet insulin secretion, an effect prevented by sepiapterin ... While a contribution of non-NO mediators can not be excluded, our results support the proposal that IL-1 beta induced, NO-mediated inhibition of insulin secretion in rat islets is dependent on the NOS cofactor BH ( 4 )
Papaccio et al., Mol Med 2002 : In summary, our findings stress that IL-1beta induced suppression of insulin secretion may be related to iNOS induction in beta cells and that RX can reverse this effect, by maintaining insulin secretion
Kato et al., Diabetologia 2003 : Furthermore, in isolated rat pancreatic islets ONO-1714 prevented IL-1beta induced inhibition of insulin secretion, this protection being evident in much lower concentrations than with L-NMMA
Corbett et al., J Clin Invest 1992 : Nitric oxide has recently been implicated as the effector molecule that mediates IL-1 beta induced inhibition of glucose stimulated insulin secretion and beta-cell specific destruction ... Pretreatment of beta-cells, purified by FACS with IL-1 beta results in a 40 % inhibition of glucose stimulated insulin secretion that is prevented by the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine ( NMMA )
Corbett et al., Biochem J 1992 : The formation of cGMP does not appear to mediate the inhibitory effects of IL-1 beta on insulin secretion since a concentration of cycloheximide ( 1 microM ) that blocks IL-1 beta induced inhibition of glucose stimulated insulin secretion and nitric oxide formation does not prevent cGMP accumulation, thus dissociating the two events ... These results show that IL-1 beta induced nitric oxide formation parallels the ability of IL-1 beta to inhibit glucose stimulated insulin secretion by islets, and that protein synthesis is required for IL-1 beta induced nitric oxide formation
Mabley et al., Pancreas 2004 (Diabetes Mellitus, Experimental...) : The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin induced diabetes in vivo and interleukin-1beta induced suppression of islet insulin secretion in vitro
Buscema et al., Metabolism 1992 : Nicotinamide partially reverses the interleukin-1 beta inhibition of glucose induced insulin release in pancreatic islets
Papaccio et al., J Cell Physiol 2005 : Our data have evidenced the following : ( i ) addition of Efaroxan to islet cultures inhibited IL-1beta activation of ICE ( cysteine protease IL-1beta converting enzyme ) while addition of 1400W did not ; ( ii ) Efaroxan completely inhibited IL-1beta induced suppression of insulin secretion and induction of iNOS mRNA transcripts, and, in addition, counteracted islet beta-cell protein profile alterations, Bax-cytochrome c translocation, caspase activation, and apoptosis ; ( iii ) 1400W inhibited IL-1beta induction of iNOS, but failed to completely counteract the other cytotoxic effects ; ( iv ) the two compounds, moreover, exerted different effects on manganese superoxide dismutase ( MnSOD ), in fact, while Efaroxan inhibited the early stimulatory effect of IL-1beta on MnSOD, 1400W did not
Kim et al., Biochem Pharmacol 2004 : Epicatechin partly restored the IL-1beta induced inhibition of insulin release
Emanuelli et al., Diabetes 2004 (Insulinoma...) : The potential role of SOCS-3 in the interleukin-1beta induced desensitization of insulin signaling in pancreatic beta-cells ... We next analyzed if suppressor of cytokine signaling (SOCS)-3, which can be induced by multiple cytokines and which we identified as an insulin action inhibitor, was implicated in the IL-1beta inhibitory effect on insulin signaling in these cells
Bendtzen et al., J Endocrinol 1992 : As shown in this paper, fusidin also prevents the inhibitory effect of human recombinant IL-1 beta ( rIL-1 beta ) and the stimulatory effect of human rIL-6, on glucose induced insulin production in vitro by normal rat pancreatic islets
Schroeder et al., Immunopharmacol Immunotoxicol 2005 : Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta mediated inhibition of glucose stimulated insulin release from cultured mouse pancreatic islets ... In this study, the antioxidants coenzyme Q10 and lipoic acid were able to block IL-1beta mediated inhibition of glucose stimulated insulin secretion from islet cells at 10 ( -12 ) M and 10 ( -9 ) M, respectively
Størling et al., Endocrinology 2005 : Finally, a chelator of intracellular free Ca ( 2+ ) [ bis- ( o-aminophenoxy ) -N, N,N ', N'-tetraacetic acid-acetoxymethyl ], an inhibitor of calmodulin ( W7 ), and inhibitors of Ca ( 2+ ) /calmodulin dependent kinase ( KN62 and KN93 ) partially reduced IL-1beta stimulated c-jun phosphorylation in INS-1 or betaTC3 cells
Andersson et al., Mol Cell Endocrinol 2005 : In iNOS-/- islets, IL-1beta at high glucose induced a delayed and prolonged stimulation of insulin secretion, and this was followed by an increase in phospholipase D mRNA expression
Sandberg et al., Biol Cell 2006 : IL-1beta caused an enhancement of islet intracellular insulin degradation and an increase in the lysosomal incorporation of beta-cell secretory granules
Larsen et al., Diabetologia 2006 (Insulinoma...) : IL-1beta induced nitric oxide production and decreases in insulin content and secretion were reduced by GADD45beta
Sjöholm et al., FEBS Lett 1991 : The protease inhibitor N alpha-p-tosyl-L-lysine chloromethyl ketone, recently shown to protect completely against IL-1 beta induced suppression of insulin production and secretion, was found to markedly reduce DNA synthesis without affecting insulin secretion
Corbett et al., J Biol Chem 1991 : Role of nitric oxide in interleukin-1 beta induced inhibition of insulin secretion ... Evidence is presented which suggests that IL-1 beta induced inhibition of insulin secretion is dependent on the metabolism of L-arginine to nitric oxide
Rydgren et al., Diabetes 2006 : IL-1beta alone induced a strong inhibition of insulin secretion and glucose oxidation rate and a marked increase in medium nitrite accumulation as an indicator of nitric oxide generation
Lagathu et al., Diabetologia 2006 (Inflammation...) : We evaluated the chronic effect ( 1-10 days ) of IL1B ( 0.1-20 ng/ml ) on insulin signalling in differentiating 3T3-F442A and differentiated 3T3-L1 murine adipocytes and in human adipocytes
Johannesen et al., Acta Endocrinol (Copenh) 1990 : During beta-cell stimulation with tolbutamide, interleukin 1 beta caused inhibition of insulin accumulation to 36 +/- 9 % of control
Welsh et al., Endocrinology 1991 : Moreover, the nitric oxide synthase inhibitor NG-monomethyl-L-arginine ( Meth-arg ; 5 mM ) failed to prevent the initial ( 90 min ) IL-1 beta induced increase in islet insulin release ... The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta induced rise in nitrite production and the IL-1 beta induced inhibition of aconitase activity and insulin release
Welsh et al., Biochem Biophys Res Commun 1992 : In rat islets this probably leads to an inhibited insulin secretion, whereas IL-1 beta in mouse islets suppresses insulin secretion by a non-mitochondrial mechanism
Oetjen et al., Diabetologia 2007 : IL-1beta and MEKK1 specifically inhibited basal and membrane depolarisation and cAMP induced INS transcription in the beta cell line ... Also, in primary islets of reporter gene mice, IL-1beta reduced glucose stimulated INS transcription ... These data suggest that IL-1beta through MEKK1 inhibits INS transcription and does so, at least in part, by decreasing MafA transcriptional activity at the RIPE3b control element
Kim et al., Pancreas 2007 : Quercetin, apigenin, and luteolin also prevented IL-1beta- and IFN-gamma mediated inhibition of insulin secretion
Shimizu et al., J Endocrinol Invest 1991 : The effect of recombinant human interleukin-1 beta ( rhIL-1b ) on in vivo insulin secretion was examined in intact and adrenalectomized ( ADX ) rats under conscious and pentobarbital anesthetized conditions
Zaitseva et al., Cell Mol Life Sci 2009 : We demonstrate that SOCS-1 does not prevent increase in NO production and decrease in glucose stimulated insulin secretion in the presence of IL-1beta , IFNgamma, TNFalpha
Welsh et al., Diabetes 1991 : It was found that the trypsin inhibitor N alpha-p-tosyl-L-lysine chloromethyl ketone ( TLCK ) counteracted the acute stimulatory effects of IL-1 beta on islet glucose oxidation, insulin release, and biosynthesis
Kapás et al., Am J Physiol 1991 (Diabetes Mellitus, Experimental) : These results indicate that, although sleep is disturbed in diabetic rats, pancreatic insulin might not have a decisive role in the regulation of sleep in rats, and it does not mediate the effects of IL-1 beta on sleep-wake activity
Wogensen et al., Autoimmunity 1990 (Body Weight...) : Previous studies have demonstrated a stimulatory effect of interleukin-1 beta (IL-1 beta) on insulin and glucagon release from the perfused rat pancreas, accompanied by selective lysis of 20 % of beta-cells as assessed by electronmicroscopy ... In pancreata from animals pre treated with IL-1 beta glucose stimulated as well as IL-1 beta potentiated glucose stimulated insulin release was almost completely abolished
Zheng et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2009 : IL-1beta induced a significant decrease of cell activity and insulin release, flow cytometry analysis showed that apoptotic percentage of islet cells remarkably increased following the addition of IL-1beta, FDP obviously improved the islets cellular activity damaged by IL-1beta, and basic amount of insulin secretion and stimulated by high glucose were improved ( P < 0.01 )
Hammonds et al., FEBS Lett 1990 (Second Messenger Systems) : The effect of the cytokine interleukin-1 beta on the insulin secretory responsiveness of single beta-cells ( HIT-T15 ) was investigated ... In the short-term, IL-1 beta induced a dosage dependent stimulation of insulin release
Beggs et al., FEBS Lett 1990 : In the short-term ( 1 h ), 25 U/ml IL-1 beta significantly increased the rates of insulin release and glucose utilisation, but not glucose oxidation ... In contrast, after 48 h, IL-1 beta inhibited insulin release and glucose utilisation and oxidation
Hughes et al., J Clin Invest 1990 : Recombinant human IL 1 beta inhibits glucose induced insulin secretion from isolated pancreatic islets and from purified beta-cells obtained by fluorescence activated cell sorting ( FACS ) of dispersed islet cells
Southern et al., Biochem J 1990 : However, IL-1 beta and IL-6 were found to inhibit insulin secretion in an additive manner
Helqvist et al., Acta Endocrinol (Copenh) 1989 : Modulation of calcium flux influences interleukin 1 beta effects on insulin release from isolated islets of Langerhans
Wogensen et al., Acta Endocrinol (Copenh) 1988 : The acute effects of recombinant human interleukin-1 beta ( rIL-1 ) on basal and glucose stimulated insulin release were investigated in the isolated perfused pancreas
Bolaffi et al., Endocrinology 1994 : The effects of several classes of agents on interleukin-1 beta (IL-1 beta) induced suppression of insulin secretion, beta-cell NAD levels, and beta-cell viability were examined
Corbett et al., Biochem J 1994 : Previous studies have shown that pretreatment of islets for 18 h with IL-1 beta results in an inhibition of glucose stimulated insulin secretion that requires 4 days incubation in the absence of IL-1 beta to restore islet secretory function
Reimers et al., Cytokine 1994 (Body Weight...) : We conclude that nitric oxide produced by the inducible form of nitric oxide synthase, mediates the IL-1 beta induced inhibition of insulin release and that the effect of IL-1 beta on temperature, pancreatic alpha-cells, and leukocyte differential counts seems to be mediated by nitric oxide produced by the constitutive form of nitric oxide synthase
Corbett et al., J Exp Med 1995 : In contrast, IL-1 beta induces the expression of iNOS and also inhibits insulin secretion by both intact islets and Facs purified beta cells, whereas TNF+LPS have no inhibitory effects on insulin secretion by purified beta cells
Eizirik et al., Mol Cell Endocrinol 1995 : Interleukin-1 beta induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation ... The aim of the present study was to investigate the mechanisms responsible for the acute, stimulatory effects of interleukin-1 beta ( rIL-1 beta ; 1 ng/ml ) on insulin release from mouse pancreatic islets
Rabuazzo et al., Diabetologia 1995 : Interleukin-1 beta inhibition of insulin release in rat pancreatic islets : possible involvement of G-proteins in the signal transduction pathway ... Cholera toxin ( 2 micrograms/ml ) or pertussis toxin ( 0.5 microgram/ml ) potentiated, as expected, glucose induced insulin release in control islets, but, in addition, when added together with IL-1 beta, were able to prevent the IL-1 beta mediated inhibition of glucose stimulated insulin secretion ( 2087 +/- 301 and 1662 +/- 173 pg.islet-1.h-1, respectively, p < 0.05 vs islets exposed to IL-1 beta alone )
Fang et al., Sheng Li Xue Bao 1995 : [ Inhibitory effect of interleukin-1 beta on insulin release from isolated rat pancreatic islets and the reversal action of testosterone ] ... This inhibitory effect of IL-1 beta on insulin release could be reversed by testosterone ( 10 ( -10 ) mol/L ), which was accompanied by an increase of the insulin content in islet cells
Green et al., Diabetologia 1993 : The inhibitory effect of SIN-1 or interleukin-1 beta on insulin secretion seems to depend to a small extent on decreased islet cyclic AMP, though sustained increases in nitric oxide or depleted islet GTP may directly affect the secretory process
Sandler et al., Immunol Lett 1994 : All three vitamin D derivatives counteracted the suppressive effect of IL-1 beta on medium insulin accumulation, 1,25- ( OH ) 2D3 being active at concentrations down to 0.1 nM, i.e., 1-2 orders of magnitude more efficacious than the analogues ... However, only KH1060 opposed the suppressive effect of IL-1 beta on islet glucose stimulated insulin secretion and glucose oxidation rate despite the fact that KH1060 itself reduced the islet DNA and insulin content by approximately 10 % and 30 %, respectively
Reusens-Billen et al., Diabetes Res Clin Pract 1994 : Pretreatment of the islets by human lysozyme does not prevent the reduction of the insulin secretion induced by IL-1 beta
Corbett et al., FASEB J 1993 : Nitric oxide has been implicated as the effector molecule that mediates interleukin-1 beta (IL-1 beta) induced inhibition of glucose stimulated insulin secretion by rat islets ... The signaling process appears to require the activation of a tyrosine kinase, since the tyrosine kinase inhibitor genistein prevents both IL-1 beta induced inhibition of insulin secretion by islets and formation of nitric oxide by the insulinoma cell line RINm5F
Reimers et al., Diabetes 1996 (Body Weight) : Isolated islets of Langerhans in vitro from Wistar-Kyoto/Mollegården ( WK/Mol ) rats were sensitive to the inhibitory effect of IL-1 beta on accumulated and acute insulin secretion, whereas islets from Brown Norway/Charles River ( BN/CR ) rats were resistant
Shimizu et al., J Endocrinol Invest 1995 : The pH dependence of interleukin-1 beta effects on insulin secretion in HIT cells
Laychock et al., Endocrinology 1996 : Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone ( EA ) or dehydroepiandrosterone ( DHEA ) and then washed responded with a concentration dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus
Sjöholm et al., Ups J Med Sci 1995 (Insulinoma...) : The cytokine IL-1 beta caused a significant decrease in both beta-cell mitogenesis and insulin accumulation, effects that were mediated through nitric oxide generation
Costantino et al., Endocrinology 1996 (Breast Neoplasms) : We examined the effects of IL-1 alpha and IL-1 beta on insulin and insulin-like growth factor I (IGF-I) stimulation of cell growth and found that both IL-1s inhibited anchorage dependent and independent growth of MCF-7 breast cancer cells
Flodström et al., Cytokine 1996 : Studies of IL-1 beta exposed rat islets revealed both NO-dependent and NO-independent effects : ( 1 ) IL-1 beta inhibits glucose induced insulin release even in the absence of NO synthesis, but this inhibition is more severe when the presence of citrulline or arginine enables NO production ; ( 2 ) NO formation in the presence of arginine or citrulline is necessary for cytokine induced inhibition of protein biosynthesis
Bleich et al., Endocrinology 1996 : IL-1 beta caused a 44 % decrease in islet G-stimulated insulin secretion compared to that in untreated islets ( P < 0.0005 ), which was totally reversed by LSF
Christensen et al., Autoimmunity 1996 : This study was undertaken to investigate the influence of Linomide on IL-1beta induced diabetogenic and hormonal changes in the rat in vivo, and on IL-1beta mediated synthesis of NO and inhibition of insulin secretion in isolated islets of Langerhans ex vivo
Kessler et al., J Leukoc Biol 1996 : In vitro, the insulin release of encapsulated islets cultured for 2 days decreased to 32 and 28 %, respectively, in the presence of IL-1beta and macrophages
de-Mello et al., Biochem Pharmacol 1996 (Insulinoma...) : However, ebselen failed to prevent the increase in nitrite production and the decrease in glucose oxidation and insulin release by rat islets exposed to IL-1 beta for 24 hr. Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines ( IL-1 beta , tumor necrosis factor-alpha and interferon-gamma )
McInerney et al., Res Commun Mol Pathol Pharmacol 1996 : Effects of a 33 residue interleukin-1 beta peptide and the antioxidant PQQ on interleukin-1 beta mediated inhibition of glucose stimulated insulin release from cultured mouse pancreatic islets ... Interleukin-1 beta (IL-1 beta) significantly inhibits insulin secretion from glucose stimulated islet cells
Mauricio et al., Cytokine 1997 : Dexamethasone prevents interleukin-1beta mediated inhibition of rat islet insulin secretion without decreasing nitric oxide production ... We aimed to assess the effect of several steroidal hormones on IL-1beta induced inhibition of rat islet insulin secretion in vitro, and their possible regulatory effects on NO production ... Incubation of newborn rat islets for 24 h in the presence of 150 pg/ml IL-1beta revealed that dexamethasone dose-dependently attenuated the inhibitory effect of IL-1beta on insulin release in response to a 2-h glucose challenge ... We conclude that dexamethasone partially protects against IL-1beta induced inhibition of rat islet insulin secretion, an effect which is not mediated through modulation of the NO pathway
Gao et al., Zhonghua Yi Xue Za Zhi 1996 : The effects of IL-1 beta and/or NA on insulin release and nitric oxide ( NO ) production and 3H-thymidine incorporation were studied
Vadakekalam et al., Am J Physiol 1997 : Interleukin-1 beta inhibits phospholipase C and insulin secretion at sites apart from KATP channel ... These data ( together with the finding that IL-1 beta inhibited Ca ( 2+ ) -induced insulin release ) suggest that, in addition to its effects on ATP synthesis and thereby on the KATP channel, IL-1 beta has at least two undescribed, distal effects to block both PLC as well as Ca ( 2+ ) -induced exocytosis
Scarim et al., Biochim Biophys Acta 1997 : The cytokine interleukin-1beta (IL-1beta) has been shown to inhibit insulin secretion and destroy pancreatic islets by a mechanism that involves the expression of inducible nitric oxide synthase (iNOS), and the production of nitric oxide ( NO ) ... We show that the interleukin-1 receptor antagonist protein ( IRAP ) prevents IL-1beta induced nitrite formation and IL-1beta induced inhibition of insulin secretion by isolated islets and primary beta-cells purified by fluorescence activated cell sorting ( FACS )
Mabley et al., FEBS Lett 1997 : Insulin-like growth factor I reverses interleukin-1beta inhibition of insulin secretion, induction of nitric oxide synthase and cytokine mediated apoptosis in rat islets of Langerhans ... Here, we demonstrate that interleukin-1beta mediated nitric oxide formation and inhibition of insulin secretion are significantly reduced by 24 h pretreatment of rat islets of Langerhans with insulin-like growth factor I (IGF-I)
Ling et al., Endocrinology 1998 : Intercellular differences in interleukin 1beta induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic beta-cells
Kwon et al., Diabetes 1998 : IL-1beta inhibits insulin secretion from pancreatic beta-cells by stimulating the expression of inducible nitric oxide synthase (iNOS) that generates the free radical nitric oxide
Larsen et al., J Biol Chem 1998 : Inhibition of p38 but not of ERK1/2 attenuated IL-1beta mediated inhibition of glucose stimulated insulin release
Ye et al., Endocrinology 1998 : Cobalt chloride ( CoCl2 ) protected islets from the inhibitory effects of IL-1beta on glucose stimulated insulin release and glucose oxidation
Wadt et al., Diabetes 1998 : IL-6 ( 10 ng/ml ) also potentiated IL-1beta mediated NO synthesis and inhibition of insulin release, whereas beta-nerve growth factor (NGF) ( 5 or 50 ng/ml ) had no effect
Park et al., Arch Biochem Biophys 1999 : IL-1beta and TNF-alpha inhibited insulin release and glucose utilization and oxidation