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Text-mined interactions from Literome

Shibasaki et al., Proc Natl Acad Sci U S A 2007 : In addition, the small GTPase Rap1 , which is activated by cAMP specifically through Epac2 in pancreatic beta cells, mediates cAMP induced insulin secretion in a protein kinase A-independent manner
Kelly et al., J Biol Chem 2010 (Diabetes Mellitus) : Activated Rap1A promotes glucose stimulated insulin secretion, islet cell hypertrophy, and islet cell proliferation, the latter exclusively through mammalian target of rapamycin complex 1, suggesting that Rap1 is an important regulator of beta-cell function
Okada et al., J Biol Chem 1997 : Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex