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INSR — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Lavan et al., J Biol Chem 1992*, Hadari et al., J Biol Chem 1992*, Okamoto et al., Biochem J 1993*, Giorgetti et al., J Biol Chem 1993*
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/IRS3 complex (INSR-INS)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Xu et al., J Biol Chem 1999*
Evidence: assay, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
INSR
—
PIK3R1
Tartare-Deckert et al., Endocrinology 1996*
-
IRef Bind Interaction:
Complex of RASA1-INSR-IRS1-PIK3R1-KHDRBS1
Sánchez-Margalet et al., FEBS Lett 1999*, Sánchez-Margalet et al., Mol Cell Endocrinol 2001*
-
IRef Bind_translation Interaction:
INSR
—
PIK3R1
(two hybrid)
Tartare-Deckert et al., Endocrinology 1996*
-
IRef Bind_translation Interaction:
INSR
—
PIK3R1
(two hybrid)
Koch et al., Oncogene 2005
-
MIPS CORUM Sam68-p85 P13K-IRS-1-IR signaling complex:
Sam68-p85 P13K-IRS-1-IR signaling complex complex (INSR-IRS1-KHDRBS1-PIK3R1)
Sánchez-Margalet et al., Mol Cell Endocrinol 2001*
-
IRef Corum Interaction:
Complex of PIK3R1-INSR-IRS1-KHDRBS1
(association, coimmunoprecipitation)
Sánchez-Margalet et al., Mol Cell Endocrinol 2001*
-
IRef Hprd Interaction:
PIK3R1
—
INSR
(in vivo)
Foukas et al., Mol Cell Biol 2004*, Klammt et al., Biochem Biophys Res Commun 2005*, Van Horn et al., J Biol Chem 1994*, Hayashi et al., J Biol Chem 1993*
-
IRef Hprd Interaction:
PIK3R1
—
INSR
(in vitro)
Foukas et al., Mol Cell Biol 2004*, Klammt et al., Biochem Biophys Res Commun 2005*, Van Horn et al., J Biol Chem 1994*, Hayashi et al., J Biol Chem 1993*
-
IRef Intact Interaction:
INSR
—
PIK3R1
(association, fluorescent resonance energy transfer)
Sato et al., Anal Chem 1999*
-
IRef Intact Interaction:
INSR
—
PIK3R1
(physical association, pull down)
Eichhorn et al., Endocrinology 2002*
-
IRef Intact Interaction:
INSR
—
PIK3R1
(physical association, pull down)
Kayali et al., J Biol Chem 1998*
-
IRef Ophid Interaction:
INSR
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Rogers et al., Diabetes 2008
(Adenovirus Infections, Human...) :
In turn, the activation of
PI3K by Ad-36 was
independent of
insulin receptor signaling but dependent on Ras signaling recruited by Ad-36
Fox et al., Cancer Res 2011
(Adenocarcinoma...) :
Inhibition of
InsR and IGF-IR with the dual tyrosine kinase inhibitor OSI-906 prevented the emergence of hormone independent cells and tumors in vivo,
inhibited parental and LTED cell growth and
PI3K/AKT signaling, and suppressed growth of established MCF-7 xenografts in ovariectomized mice, whereas treatment with the neutralizing IGF-IR monoclonal antibody MAB391 was ineffective
He et al., Ann Oncol 2012
(Breast Neoplasms...) :
Human epidermal growth factor receptor ( HER2 ),
insulin receptor and IGF-I receptor
involve the same
PI3K/AKT/mTOR signaling, and different antidiabetic pharmacotherapy may differentially affect this pathway, leading to different prognoses of HER2+ breast cancer
Kenzel et al., J Immunol 2012
(Inflammation...) :
We found that GBS induced, MyD88 dependent chemokine formation of PML was specifically downmodulated by insulin via
insulin receptor mediated induction of
PI3K