UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to CD14

CD14 — IRAK1

Pathways - manually collected, often from reviews:

BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1) → TRAF6 (modification, activates)
BioCarta toll-like receptor pathway: CD14 → LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) (modification, collaborate)
BioCarta toll-like receptor pathway: CD14 → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta toll-like receptor pathway: None → LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) (modification, collaborate)
BioCarta toll-like receptor pathway: LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14) → CD14/LBP complex (CD14-EHHADH) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14) → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: CD14/LBP complex (CD14-EHHADH) → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2) → TRAF6 (modification, activates)
BioCarta toll-like receptor pathway: CD14 → TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1) (modification, collaborate)
BioCarta toll-like receptor pathway: CD14 → TLR2/TLR6/MYD88/IRAK complex (IRAK1-MYD88-TLR6-TLR2) (modification, collaborate)
BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1) → TLR2/TLR6/MYD88/IRAK complex (IRAK1-MYD88-TLR6-TLR2) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14) (ceramide biosynthetic process, activates)
BioCarta toll-like receptor pathway: LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) → TRAF6 (modification, activates)
BioCarta toll-like receptor pathway: CD14 → TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2) (modification, collaborate)
BioCarta toll-like receptor pathway: CD14 → TLR2/TLR2/MYD88/IRAK complex (MYD88-IRAK1-TLR2) (modification, collaborate)
BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2) → TLR2/TLR2/MYD88/IRAK complex (MYD88-IRAK1-TLR2) (modification, collaborate)
Reactome Reaction: CD14 → IRAK1 (indirect_complex) Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Rao et al., Mol Cell Biol 2005, Keating et al., J Biol Chem 2007, Gottipati et al., Cell Signal 2008, Wan et al., J Biol Chem 2009, Lin et al., Nature 2010, Flannery et al., J Biol Chem 2011
Reactome Reaction: CD14 → IRAK1 (reaction) Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Rao et al., Mol Cell Biol 2005, Keating et al., J Biol Chem 2007, Gottipati et al., Cell Signal 2008, Wan et al., J Biol Chem 2009, Lin et al., Nature 2010, Flannery et al., J Biol Chem 2011