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IL1B — IRAK4

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IRAK4 (IRAK4) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88 complex (IL1B-IL1R1-IL1RAP-MYD88) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK4 (IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88s complex (IL1B-IL1R1-IL1RAP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK4 (IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88 complex (IL1B-IL1R1-IL1RAP-MYD88) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IRAK/TOLLIP complex (IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IRAKM (IRAK3) (modification, collaborate) Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAK/TOLLIP complex (IRAK1-TOLLIP) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAKM (IRAK3) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, inhibits)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → TRAF6 (TRAF6) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) (modification, collaborate)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, activates)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) → IRAK (IRAK1) (modification, activates) Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: IL1B → IRAK4 (reaction) Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003, Kollewe et al., J Biol Chem 2004, Brikos et al., Mol Cell Proteomics 2007*, Gottipati et al., Cell Signal 2008
• Reactome Reaction: IL1B → IRAK4 (indirect_complex) Burns et al., J Exp Med 2003, Cheng et al., Biochem Biophys Res Commun 2007, Brikos et al., Mol Cell Proteomics 2007*

Text-mined interactions from Literome

Wan et al., Cell Signal 2001 : However, IL-1beta induced IRAK activation was not affected by PD153035
Ferlito et al., J Leukoc Biol 2001 (Leukemia, Monocytic, Acute...) : However, neither TNF-alpha nor IL-1beta induced IRAK degradation or stimulated TNF-alpha or TxB2 production in naive cells
Igwe et al., Eur J Neurosci 2003 : Stimulation of IL-1 receptor by IL-1beta may induce the phosphorylation of tyrosine residues in many effector proteins through the activation of p60c-src kinase
Russo et al., Cell Signal 2004 : Despite similar 125I-IL-1beta binding, HT-29 cells displayed no IRAK degradation, a 75 % reduction of IKK activity, and decreased IkappaBalpha phosphorylation, NF-kappaB DNA binding activity and IL-8 mRNA accumulation in response to IL-1beta compared to Caco-2 cells
Srinivasan et al., J Neurosci 2004 : Neurons as well as astrocytes in the hippocampus also express the type 1 IL-1 receptor , indicating that this cytokine can influence neuronal function directly, yet IL-1beta does not induce production of cytokines in neurons as it does in glia
Chen et al., Proc Natl Acad Sci U S A 2006 (Aortic Diseases...) : PDGF-BB/IL-1beta induced a sustained phosphorylation of PDGF receptor (PDGFR)-beta and its association with IL-1 receptor ( IL-1R1 )
Shu et al., Respir Physiol Neurobiol 2007 : PC12 cells express IL-1 receptor type I and response to IL-1beta stimulation
Rutkute et al., Hepatology 2007 : These age related changes in JNK phosphorylation correlated with diminished IL-1beta induced degradation of interleukin-1 receptor associated kinase-1 ( IRAK-1 )
Yego et al., Invest Ophthalmol Vis Sci 2009 : Inhibition of the IL-1 receptor using an IL-1 receptor antagonist ( IL-1ra ; 50 ng/mL ) or inhibition of IL-1beta production using a specific caspase-1 inhibitor ( YVAD-fmk ; 100 microM ) significantly decreased high glucose induced GAPDH nuclear accumulation
Ahmad et al., J Immunol 2009 : The role and relative contribution of MyD88, IRAK1 , and TRAF6 adaptor proteins in IL-1beta regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown ... By small interfering RNAs mediated knockdown, we show that IL-1beta induced up-regulation of ADAMTS-4 in chondrocytes requires MyD88, IRAK1 , and TRAF6 adaptor proteins
Bristulf et al., Neurosci Lett 1995 : IL-1 beta increased type I IL-1 receptor mRNA levels within 1 h, with elevated levels remaining after 24 h, whereas it induced a bell shaped alteration of type II IL-1 receptor mRNA levels, with a peak after 6 h. Tumour necrosis factor-alpha (TNF alpha) similarly up-regulated type II IL-1 receptor mRNA levels, and type I IL-1 receptor mRNAs albeit to a lesser extent than IL-1 beta
Symons et al., Proc Natl Acad Sci U S A 1995 : These observations suggest that the type II sIL-1R inhibits IL-1 beta at two steps, by preventing processing of propeptide and by blocking the interaction of mature IL-1 beta with type I IL-1 receptor
Takahashi et al., Am J Physiol 1996 (Fever) : We report here the effects of a synthetic IL-1 receptor fragment corresponding to amino acid residues 86-95 of the human type I IL-1 receptor ( IL-1RF ) on spontaneous sleep and IL-1 beta- and MDP induced sleep and fever in rabbits
Chizzolini et al., Eur J Immunol 1997 (Inflammation) : Human Th1 cells preferentially induce interleukin (IL)-1beta while Th2 cells induce IL-1 receptor antagonist production upon cell/cell contact with monocytes
Shirachi et al., Kurume Med J 1998 (Inflammatory Bowel Diseases) : Conversely, neutralization of endogenous IL-10 was found to augment both tumor necrosis factor-alpha and IL-1 beta production and inhibit IL-1 receptor antagonist production