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IRAK4 — MAP3K7
Text-mined interactions from Literome
Takaesu et al., Mol Cell Biol 2001
(MAP Kinase Signaling System) :
In this report, we investigate the
role of
IRAK in the activation of
TAK1 ... Genetic analysis reveals that
IRAK is
required for IL-1 induced activation of
TAK1
Qian et al., J Biol Chem 2001
:
Our results show that
IRAK is
required for the IL-1 induced phosphorylation of
TAK1 , TAB1, and TAB2
Xiao et al., J Biol Chem 2008
:
Importantly, the negative impact of Pellino 3b on IL-1 induced IRAK degradation correlated with the inhibitory effect of Pellino 3b on the IL-1 induced TAK1 dependent pathway, suggesting that a positive role of
IRAK degradation in IL-1
induced TAK1 activation
Xiong et al., J Biol Chem 2011
:
We report that endotoxin tolerization of THP1 cells and human monocytes impairs LPS mediated receptor recruitment and activation of
IRAK4 , ablates K63 linked polyubiquitination of IRAK1 and TRAF6, compromises assembly of IRAK1-TRAF6 and IRAK1-IKK? platforms, and
inhibits TAK1 activation