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IRF1 — PIK3R1
Text-mined interactions from Literome
Kokkinakis et al., Cancer Lett 2006
(Neoplasms) :
The response of tumors to MET-stress depends on their mutational status, however, it always involves inhibition of CDK1 and in most cases the upregulation of p21, p27, GADDs and 14-3-3sigma in
response to upregulation of TGF-beta,
IRF-1 , TNF-alpha, Rb and/or MDA-7 and the downregulation of
PI3K , RAS and NF-kappaB
Kanda et al., Eur J Immunol 2007
:
Inhibitors of
PI3 K , p38 MAPK, and MEK
suppressed IL-18 plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB, STAT1, and
IRF-1 activities