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IRF6 — PLD6

Text-mined interactions from Literome

Zhang et al., Int Immunopharmacol 2001 : Phosphatidic acid was reduced to basal level by butanol after LPS stimulation for 2.5 min and by butanol plus D609 after LPS stimulation for 2.5 or 10 min. Taken together, these data indicate that activation of RAW264.7 cells by LPS can be mediated by the activities of both PC-PLC and PC-PLD
Conquer et al., Osteoarthritis Cartilage 1994 : Although PMA is known to stimulate phospholipase D ( PLD ) activity in most cells, it is not known whether LPS and IL-1 also stimulate PLD activity, or whether PLD activity contributes to AA liberation and PGE2 production in chondrocytes ... In the present study we compared the effect of IL-1, LPS and protein kinase C ( PKC ) activators ( PMA ), mezerein, phorbol dibutyrate on PGE2 synthesis and PLD activity in articular chondrocytes
Park et al., FEBS Lett 2002 : Unstimulated PLD activity in cultured cells for 20 h was higher than that in freshly isolated cells and further increased in cultured cells with LPS
Chien et al., Chin J Physiol 2004 : Our results indicated that ( 1 ) LPS stimulated pHi elevation was PKC dependent ; ( 2 ) After 30 min stimulation, LPS increased PLD activity via a measured production of 3H-phosphatidylethanol from phosphatidic acid and the initiation of PLD1a mRNA expression started ; ( 2 ) LPS stimulated IL-2 R expression but not IL-2 and IL-4 secretion ... Our findings suggested that the stimulation of PLD activity and its mRNA expression by LPS might be required for IL-2 R expression and a sustained PKC dependent pHi elevation but not for the secretion of IL-2 or IL-4 in human T cells
Tardy et al., Biomed Sci Instrum 2008 : Our hypothesis is that activation of the phosphatidylcholine-phospholipase D ( PC-PLD ) pathway leading to phosphatidic acid production plays a role in both cytokine and LPS signaling in macrophages
Lee et al., Mol Pharmacol 2010 : In addition, LPS or phorbol 12-myristate 13-acetate stimulated PLD activity, and the pretreatment of PLD inhibitor weakened foam cell formation and recovered RGS2 down-regulation
Yasui et al., Infect Immun 1994 : We investigated the effects of a monoclonal antibody against CD14 ( MY4 ) and of pentoxifylline (POF), a membrane fluidizer, alone and in combination, on LPS-LPS binding protein activation of phospholipase D evidenced by increased phosphatidic acid formation
Chow et al., New Horiz 1995 : PLD is stimulated by LPS to release phosphatidic acid ( PA )
Natarajan et al., Biochim Biophys Acta 1994 : Lipopolysaccharide (LPS) induced phospholipase D ( PLD ) activation was investigated in undifferentiated monocytic leukemic cell lines THP-1 and U-937 ... LPS mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine ( 2 microM ) and by protein kinase C ( PKC ) down-regulation with 12-O-tetradecanoylphorbol 13-acetate ( TPA ) suggesting a role for PKC ... These results indicate that an increase in intracellular Ca2+ is necessary for LPS mediated PLD activation
Chen et al., J Biol Chem 1998 : These data suggest that in astrocytes, LPS might activate phosphatidylcholine-phospholipase C and phosphatidylcholine-phospholipase D through an upstream protein tyrosine kinase to induce PKC activation