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ISL1 — MMP27

Text-mined interactions from Literome

Kang et al., J Nutr Biochem 2010 (Neovascularization, Pathologic) : This study examined the inhibitory effects of isoliquiritigenin ( ISL ) on phorbol myristate acetate ( PMA ) -induced MMP production and its tissue inhibitor of MMP (TIMP) in endothelial cells ... ISL dose-dependently suppressed PMA induced expression and activity of MMP-2 and membrane type 1-MMP at > or=1 microM while diminishing the elevated MMP-2 transcript level ... Therefore, the ISL inhibition of MMP may boost a therapeutic efficacy during angiogenesis
Wang et al., Expert Opin Ther Targets 2013 (Breast Neoplasms...) : Objectives : The purpose of this study is to investigate the effects of ISL on VEGF and MMP expression in highly metastatic human breast cancer cell line, MDA-MB-231