◀ Back to PIK3R1
ITGA6 — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database a6b1 and a6b4 Integrin signaling:
alpha6/beta4 Integrin/Met complex (ITGA6)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Trusolino et al., Cell 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database a6b1 and a6b4 Integrin signaling:
alpha6/beta4 Integrin/Met complex (ITGA6)
→
alpha6/beta4 Integrin/Met /SHC/PI3K complex (ITGA6-SHC1-PIK3CA-PIK3R1)
(modification, collaborate)
Trusolino et al., Cell 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database a6b1 and a6b4 Integrin signaling:
PI3K complex (PIK3CA-PIK3R1)
→
alpha6/beta4 Integrin/Met /SHC/PI3K complex (ITGA6-SHC1-PIK3CA-PIK3R1)
(modification, collaborate)
Trusolino et al., Cell 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database a6b1 and a6b4 Integrin signaling:
SHC (SHC1)
→
alpha6/beta4 Integrin/Met /SHC/PI3K complex (ITGA6-SHC1-PIK3CA-PIK3R1)
(modification, collaborate)
Trusolino et al., Cell 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database a6b1 and a6b4 Integrin signaling:
alpha6/beta4 Integrin/Laminin complex (ITGA6-ITGB4)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Chartier et al., J Cell Sci 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database a6b1 and a6b4 Integrin signaling:
alpha6/beta4 Integrin/Laminin complex (ITGA6-ITGB4)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Chartier et al., J Cell Sci 2006, Shaw et al., Cell 1997*
Evidence: assay
Text-mined interactions from Literome
Shaw et al., Mol Cell Biol 2001
(Neoplasm Invasiveness) :
In the present study, we investigated the signaling pathway by which the
alpha6beta4 integrin activates
PI3K ... We identified insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the
activation of
PI3K by the
alpha6beta4 integrin
Santoro et al., Dev Cell 2003
:
We show that growth factor macrophage stimulating protein (MSP)- and its receptor Ron mediated
PI3K activation in keratinocytes
induces phosphorylation of both Ron and
alpha6beta4 integrin at specific 14-3-3 binding sites