Shaw et al., Mol Cell Biol 2001
(Neoplasm Invasiveness) :
In the present study, we investigated the signaling pathway by which the alpha6beta4 integrin activates PI3K ... We identified insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the activation of PI3K by the alpha6beta4 integrin Santoro et al., Dev Cell 2003
:
We show that growth factor macrophage stimulating protein (MSP)- and its receptor Ron mediated PI3K activation in keratinocytes induces phosphorylation of both Ron and alpha6beta4 integrin at specific 14-3-3 binding sites