Gene interactions and pathways from curated databases and text-mining

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ITGB4 — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Shaw et al., Mol Cell Biol 2001 (Neoplasm Invasiveness) : In the present study, we investigated the signaling pathway by which the alpha6beta4 integrin activates PI3K ... We identified insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the activation of PI3K by the alpha6beta4 integrin
Santoro et al., Dev Cell 2003 : We show that growth factor macrophage stimulating protein (MSP)- and its receptor Ron mediated PI3K activation in keratinocytes induces phosphorylation of both Ron and alpha6beta4 integrin at specific 14-3-3 binding sites