◀ Back to IL18
IL18 — JAK2
Pathways - manually collected, often from reviews:
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NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Rodriguez-Galán et al., J Immunol 2005
Evidence: assay, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, activates)
Parham et al., J Immunol 2002
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Schindler et al., J Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
Text-mined interactions from Literome
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Walker et al., Arch Virol Suppl 2005
(Ehrlichiosis) :
Ehrlichiae attach to L-selectin and E-selectin,
inhibit phagolysosomal fusion, apoptosis, and
JAK/STAT activation, and downregulate IL-12, IL-15,
IL-18 , TLR2 and 3, and CD14
Wang et al., Blood 2008
(MAP Kinase Signaling System) :
IL-12 and
IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was
mediated by Janus kinase-signal transducers and activators of transcription (
JAK-STAT ) -dependent signaling without induction of calcium flux