Gene interactions and pathways from curated databases and text-mining

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IL18 — JAK2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Walker et al., Arch Virol Suppl 2005 (Ehrlichiosis) : Ehrlichiae attach to L-selectin and E-selectin, inhibit phagolysosomal fusion, apoptosis, and JAK/STAT activation, and downregulate IL-12, IL-15, IL-18 , TLR2 and 3, and CD14
Wang et al., Blood 2008 (MAP Kinase Signaling System) : IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was mediated by Janus kinase-signal transducers and activators of transcription ( JAK-STAT ) -dependent signaling without induction of calcium flux