◀ Back to PIK3R1
JAK2 — PIK3R1
Pathways - manually collected, often from reviews:
-
KEGG Jak-STAT signaling pathway:
JAK1/JAK2/JAK3/TYK2
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, phosphorylation)
-
KEGG Cholinergic synapse:
JAK2
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database IL23-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, activates)
Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2)
→
PI3K Class I family (PIK3CA/PIK3R1/PIK3CB/PIK3R1/PIK3CG/PIK3R6)
(modification, activates)
Zhang et al., Blood 2001
Evidence: assay, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA)
(modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL5-mediated signaling events:
IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2 complex (CSF2RB-IL5-IL5RA-JAK2)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Dijkers et al., Oncogene 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Nguyen et al., J Biol Chem 2001, Deb et al., J Immunol 2003
Evidence: mutant phenotype
-
Reactome Reaction:
JAK2
→
PIK3R1
(reaction)
Wickrema et al., J Biol Chem 1999, Guthridge et al., Mol Cell 2000, Gu et al., Mol Cell 1998
-
Reactome Reaction:
JAK2
→
PIK3R1
(indirect_complex)
Guthridge et al., Mol Cell 2000
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
JAK3/JAK2/JAK1
→
PIK3CA/PIK3R1/PIK3IP1/PIK3R2/PIK3CB/PIK3CD/PIK3R4
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PIK3R1
—
JAK2
(direct interaction, pull down)
Ren et al., Mol Cell Biol 2005*
-
IRef Biogrid Interaction:
PIK3R1
—
JAK2
(physical association, affinity chromatography technology)
Fuhrer et al., Biochem Biophys Res Commun 1996*
-
IRef Hprd Interaction:
PIK3R1
—
JAK2
(in vivo)
Fuhrer et al., Biochem Biophys Res Commun 1996*
-
IRef Hprd Interaction:
PIK3R1
—
JAK2
(in vitro)
Fuhrer et al., Biochem Biophys Res Commun 1996*
-
IRef Intact Interaction:
PIK3R1
—
JAK2
(physical association, peptide array)
Wu et al., Proteomics 2007
-
IRef Intact Interaction:
Complex of STAT5A-JAK2-CSF2RB-PIK3R1-AKT1
(association, anti bait coimmunoprecipitation)
Guthridge et al., EMBO J 2006
-
IRef Ophid Interaction:
PIK3R1
—
JAK2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Krasilnikov et al., Oncogene 2003
(Melanoma) :
Tyrosine phosphorylation of STAT3/5 and of JAK2 also increased upon treatment of LU1205 cells with either PD or LY, suggesting that constitutive active MAPK and
PI3K signals
inhibit tyrosine phosphorylation of
JAK/STATs
Choudhury et al., Metabolism 2006
:
These effects were blocked by
JAK2 inhibition as well as
PI3K inhibition
Naito et al., Nagoya J Med Sci 2005
:
AG-490, a
Jak-2 inhibitor, or LY294002, a
PI3K inhibitor , similarly suppressed the augmented production of hyarulonan
Luo et al., Eur J Neurosci 2007
(Optic Nerve Injuries) :
In this study we showed that : ( i ) the RGC protection was pathway inhibition dependent ; ( ii ) inhibition of PI3K/akt and
JAK/STAT , but not MEK/ERK, activated macrophages in the eye, ( iii ) macrophage removal from the eye using clodronate liposomes significantly impeded PI3K/akt and JAK/STAT inhibition
induced RGC survival and axon regeneration whereas it only slightly affected MEK/ERK inhibition dependent protection ; ( iv ) in the absence of recruited macrophages in the eye, inhibition of PI3K/akt or JAK/STAT did not influence RGC survival ; and ( v ) strong
PI3K/akt , JAK/STAT and MEK/ERK pathway activities were located in RGCs but not macrophages after ON injury
Huang et al., J Immunol 2007
:
Requirement for both
JAK mediated
PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Lin et al., Toxicol In Vitro 2010
(Breast Neoplasms) :
Moreover, the JAK2 inhibitor AG490 blocked JAK2, STAT3, Src, PI3K, and Akt activation, whereas both Src inhibitor PP2 and
PI3K inhibitor wortmannin did not
affect JAK2 activation
Su et al., Clin Exp Pharmacol Physiol 2010
:
These observations suggest that
PI3-K is an upstream
activator of
JAK2/STAT3
Li et al., PloS one 2012
(Hypereosinophilic Syndrome) :
Interestingly,
JAK2 inhibition also
reduced PI3K , Akt and NF-?B activity in a dose dependent manner, and suppressed expression levels of c-Myc and Survivin ... Interestingly,
JAK2 inhibition also
reduced PI3K , Akt and NF-?B activity in a dose dependent manner, and suppressed expression levels of c-Myc and Survivin
Chang et al., Gen Comp Endocrinol 2012
:
The specific inhibitors of either MEK1 ( U-0126 and PD-98059 ),
JAK ( AG-490 ), JNK ( SP-600125 ), or PI3K ( LY-294002 and wortmannin ) reduced ET-1 increased levels of SOCS-3 mRNA and respectively
inhibited ET-1 stimulated activities of MEK1, JAK, JNK, and
PI3K
Britschgi et al., Cancer Cell 2012
(Breast Neoplasms...) :
Mechanistically,
PI3K/mTOR inhibition
increased IRS1 dependent activation of
JAK2/STAT5 and secretion of IL-8 in several cell lines and primary breast tumors