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AGTR1 — JUN
Text-mined interactions from Literome
Wu et al., Free Radic Biol Med 2005
:
Together, these findings indicate that Ang-II elicits the
activation of the redox-sensitive
AP-1 via ROS through
AT1 , resulting in effects on cardiomyocyte function such as hypertrophy
Liu et al., Circ Res 2006
(Body Weight...) :
Neuronal
angiotensin II type 1 receptor upregulation in heart failure :
activation of
activator protein 1 and Jun N-terminal kinase
Zucker et al., Am J Physiol Heart Circ Physiol 2009
(Chronic Disease...) :
There is now good evidence that
AT(1)R expression in neurons is
mediated by activation of the transcription factor
activator protein 1 (AP-1)
Wang et al., Zhonghua Shao Shang Za Zhi 2010
(Acute Lung Injury) :
[
Role of
angiotensin II type 1 receptor in activation of nuclear factor-kappaB and
activator protein-1 in lung of mice with acute lung injury ] ... To explore the
role of
angiotensin II type 1 (AT1) receptor in activation of nuclear factor-kappaB (NF-kappaB) and
activator protein-1 (AP-1) in lung of mice with LPS induced acute lung injury ( ALI )
Wang et al., Experimental biology and medicine (Maywood, N.J.) 2012
(Inflammation) :
Forced over-expression of
AT1R resulted in activation of MAPKs,
c-Jun and NF-?B, up-regulation of inflammatory genes and LOX-1 ; on the other hand forced AT2R over-expression induced up-regulation of pro-apoptotic signals ( pro-IL-1ß and IL-1ß ), and decreased LOX-1 expression