Gene interactions and pathways from curated databases and text-mining

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AKT1 — KIT

Text-mined interactions from Literome

Duensing et al., Oncogene 2004 (Gastrointestinal Neoplasms) : Using GIST in vitro models, we showed that activation of MAPK p42/44, AKT , and S6K was KIT dependent , whereas STAT1 and STAT3 phosphorylation was only partially dependent on KIT activation
Shaw et al., Gynecol Oncol 2007 (Ovarian Neoplasms) : AKT mediates the pro-survival effects of KIT in ovarian cancer cells and is a determinant of sensitivity to imatinib mesylate
Lin et al., J Med Chem 2009 (Lung Neoplasms) : We further confirmed that PBT-1 suppressed Akt activation accelerated RelA degradation via IkappaB kinase-alpha and down-regulated NF-kappaB target gene expression
Phung et al., PloS one 2011 : Using specific inhibitors we observe and verify that c-KIT induced activation of Mitf is dependent on PI3-, Akt- , Src-, p38- or Mek kinases
Brahimi-Adouane et al., Mol Oncol 2013 : ER inhibitors also inhibited KIT activation dependent phosphorylation of AKT and ERK1/2