Gene interactions and pathways from curated databases and text-mining

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KIT — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ueda et al., Blood 2002 (Calcium Signaling) : In Y719F, the binding of phosphatidylinositol 3'-kinase (PI3K) to KIT was lost and KIT mediated cell migration and Ca ( 2+ ) mobilization were suppressed by PI3K chemical inhibitors or dominant negative PI3K , suggesting the involvement of Y719 mediated PI3K pathway in cell migration
Koma et al., Lab Invest 2005 : KIT-Y719F does not activate PI3-K , whereas KIT-Y821F does
Zhu et al., Oncogene 2007 (Gastrointestinal Stromal Tumors) : Activated signaling intermediates were identified by immunoaffinity purification of tyrosine phosphorylated proteins in GIST cells before and after treatment with KIT inhibitors, and these analyses show that GRB2, SHC, CBL and MAPK activation are largely KIT dependent in GISTs, whereas PI3-K , STAT1 and STAT3 activation are partially KIT dependent