Gene interactions and pathways from curated databases and text-mining

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KITLG — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sui et al., Br J Haematol 2000 : Interestingly, both EPO and SCF induced activation of PI3K
Chian et al., Blood 2001 (Cell Transformation, Neoplastic) : SCF stimulates association of p85PI3K with phosphorylated tyrosine 721 of wild-type c-Kit
Krystal et al., Mol Cancer Ther 2002 (Carcinoma, Small Cell...) : Both stem cell factor (SCF) and insulin-like growth factor (IGF)-I, components of prominent small cell lung cancer ( SCLC ) autocrine loops, as well as FCS, can potently activate phosphatidylinositol 3-kinase (PI3K)-Akt signaling, albeit with different kinetics ... SCF induced PI3K-Akt activation occurs rapidly but fades within 60 min ; IGF-I and FCS induced activation persists for at least 6 h. SCF and IGF-I mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling
Jeon et al., Pigment Cell Melanoma Res 2009 : Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration