Gene interactions and pathways from curated databases and text-mining

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CFTR — KRT18

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Stanke et al., BMC medical genetics 2011 (Cystic Fibrosis) : KRT8, but not KRT18 , showed an association with CF disease severity ( Pbest=0.00131 ; Pcorr=0.0185 ) and CFTR mediated residual chloride secretion ( Pbest=0.0004 ; Pcorr=0.0069 )
Duan et al., J Biol Chem 2012 (Cystic Fibrosis) : Overexpression of K18 in cells robustly increased the surface expression of wild-type CFTR , whereas depletion of K18 through RNA interference specifically diminished it ... K18 binding increased the surface expression of CFTR by accelerating its apical recycling rate without altering CFTR biosynthesis, maturation, or internalization ... Taken together, our results suggest that K18 increases the cell surface expression of CFTR by interacting with the CFTR C-terminal hydrophobic patch