Gene interactions and pathways from curated databases and text-mining

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LCK — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sagan et al., Biochem Biophys Res Commun 2008 (Nijmegen Breakage Syndrome) : We provide evidence that the observed reduced PI3K activity in NBS lymphoblasts is caused by an impaired expression of the SFKs LCK and/or HCK
Salmond et al., J Immunol 2009 : We show that maximal TCR induced rpS6 phosphorylation in CD8 T cells requires both Lck and Fyn activity and downstream activation of PI3K , mTOR, and MEK/ERK MAPK pathways
von Willebrand et al., Eur J Immunol 1994 : We also show that p56lck directly activates PI3K purified from transfected COS-1 cells, indicating that other T cell-specific proteins are not required for the process ... Our results suggest that p56lck is required for activation of PI3K in Jurkat T cells and can itself directly activate it by phosphorylating one or several stimulatory sites
Lu et al., J Immunol 1998 : CD28 induced association of EMT with PI3K also requires functional expression of LCK