Gene interactions and pathways from curated databases and text-mining

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LCK — SYK

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Chakraborty et al., J Biol Chem 2006 (Anoxia...) : Accordingly, we hypothesized that hypoxia/reoxygenation ( H/R ) may play an important role in regulating Syk activation, and Lck may be involved in this process
Couture et al., Mol Cell Biol 1994 : Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation ... Coexpression of lck did not alter the catalytic activity of p72syk, but the expressed p56lck was much more active in the presence of p72syk than when expressed alone
Williams et al., Eur J Biochem 1997 : We have previously reported that the activation of Syk is less dependent on the Src family kinase Lck than the activation of Zap