Gene interactions and pathways from curated databases and text-mining

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LDLR — PIK3R1

Text-mined interactions from Literome

Borradaile et al., Diabetes 2003 (Carcinoma, Hepatocellular...) : Insulin and naringenin induced PI3K dependent increases in cytosolic and nuclear SREBP-1 and LDLr expression
Guo et al., Cancer Discov 2011 (Brain Neoplasms...) : These results show that EGFRvIII can promote tumor survival through PI3K/SREBP-1 dependent upregulation of LDLR and suggest a role for LXR agonists in the treatment of GBM patients