Borradaile et al., Diabetes 2003
(Carcinoma, Hepatocellular...) :
Insulin and naringenin induced PI3K dependent increases in cytosolic and nuclear SREBP-1 and LDLr expression
Guo et al., Cancer Discov 2011
(Brain Neoplasms...) :
These results show that EGFRvIII can promote tumor survival through PI3K/SREBP-1 dependent upregulation of LDLR and suggest a role for LXR agonists in the treatment of GBM patients