Gene interactions and pathways from curated databases and text-mining

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LEP — PIK3R1

Text-mined interactions from Literome

Niswender et al., Diabetes 2003 (Anorexia...) : These findings support the hypothesis that the IRS-PI3K pathway is a mediator of insulin action in the arcuate nucleus and, combined with recent evidence that leptin activates PI3K signaling in the hypothalamus, provide a plausible mechanism for neuronal cross-talk between insulin and leptin signaling
Lee et al., Experimental biology and medicine (Maywood, N.J.) 2003 : Leptin may stimulate PI 3-K to constrain PLC-PKC induced insulin secretion from islets of Lep ( ob ) /Lep ( ob ) mice
Niswender et al., J Histochem Cytochem 2003 : We conclude that immunocytochemical PIP3 staining can detect changes in PI3K activation induced by insulin and leptin in cell culture and intact liver
Solinas et al., FEBS Lett 2004 : Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by substrate cycling between de novo lipogenesis and lipid oxidation, and that this cycle requires both PI3K and AMPK signaling
Benomar et al., Biochem J 2005 : Furthermore, leptin or insulin pre-treatment increased basal PI3K activity and IRS-1 or IRS-2 association with p85 and abolished acute insulin or leptin effect, in addition to the down-regulation of IRS-1 and IRS-2
Xu et al., J Clin Invest 2005 (Synaptic Transmission) : We developed mice in which a fluorescent reporter for PI3K activity is targeted to either Agrp or POMC neurons and used 2-photon microscopy to measure dynamic regulation of PI3K by insulin and leptin in brain slices
Aquila et al., J Clin Endocrinol Metab 2005 : In uncapacitated sperm, both insulin and leptin increased PI3K activity, Akt S473, and glycogen synthase kinase-3 S9 phosphorylation
Morrison et al., Am J Physiol Endocrinol Metab 2005 : Because NPY/AgRP neurons project to the hypothalamic paraventricular nucleus ( PVN ), we next investigated whether leptin activation of PVN neurons is similarly PI3K dependent ... We conclude that leptin requires intact PI3K signaling both to inhibit hypothalamic Npy and Agrp gene expression and activate neurons within the PVN
Morton et al., Cell Metab 2005 (Body Weight) : These findings suggest that hypothalamic leptin signaling is an important determinant of glucose metabolism and that the underlying neuronal mechanism involves PI3K
Zeidan et al., J Pharmacol Exp Ther 2007 (Hypertrophy) : Our results indicate that the activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
Metlakunta et al., Endocrinology 2008 (Body Weight...) : Leptin ( ip ) significantly increased hypothalamic PI3K activity and phosphorylated signal transducer and activator of transcription 3 ( p-STAT3 ) levels in LFD fed mice but not in DIO mice
Plum et al., Cell Metab 2007 (Thinness) : Enhanced leptin stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation ... These data provide direct genetic evidence that leptin stimulated Pi3k signaling in the CNS regulates energy expenditure via activation of SNA to perigonadal WAT leading to BAT-like differentiation of WAT
Rafail et al., Thromb Res 2008 (Inflammation...) : Inhibition studies revealed that the effect of leptin on TF expression is mediated , at least in part, by JAK2 and PI3K
Hill et al., J Clin Invest 2008 (Body Weight) : Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice ... It has been proposed that leptin action requires PI3K activity
Jiang et al., Hepatology 2008 : We found that leptin induced the PI3K dependent activation of Rac1, and that nicotinamide adenine dinucleotide phosphate, reduced form ( NADPH ) oxidase activation was also implicated in this process
Roman et al., Mol Cell Endocrinol 2010 : Central leptin action requires PI3K activity to modulate glucose homeostasis and peripheral metabolism
Uddin et al., Endocr Relat Cancer 2010 (Carcinoma, Papillary...) : Inhibition of PI3K activity by its inhibitor LY294002 abrogated leptin mediated PI3K/AKT signaling
Heldsinger et al., J Biol Chem 2011 (Ion Channel Gating) : Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways : implications for leptin as a regulator of short term satiety
Metlakunta et al., Am J Physiol Regul Integr Comp Physiol 2011 (Obesity...) : In food restricted WT mice with reduced body weight, leptin increased hypothalamic PI3K activity only at 30 min, and p-STAT3 levels at 30-120 min postinjection ... In the next experiment with a clonal hypothalamic neuronal cell line expressing proopiomelanocortin, we observed that whereas leptin significantly increased IRS1 associated PI3K activity and p-JAK2 levels in cells transfected with control vector, it failed to do so in SOCS3 overexpressed cells
Williams et al., J Neurosci 2011 : The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
Xu et al., Hepatogastroenterology 2011 (Fatty Liver) : Leptin may be involved in NAFLD pathogenesis by activating the PI3-K/Akt kinase pathway via OB-R and the defective leptin activation of PI3-K is a novel mechanism of leptin resistance in NAFLD
Warne et al., Cell Metab 2011 (Fatty Liver) : Impairment of central leptin mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity ... Attenuation of leptin induced PI3K signaling, brought about by transgenic expression of phosphatase and tensin homolog (PTEN) in leptin receptor neurons, leads to decreased hepatic sympathetic tone and increased triglyceride levels without affecting adiposity or hepatic insulin signaling
Sahu et al., J Neuroendocrinol 2013 : In the hypothalamus, leptin stimulates STAT3 activation, and induces PI3K and PDE3B activities, among others
Pijet et al., Cytokine 2013 (MAP Kinase Signaling System) : Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both JAK/STAT3 and MEK/MAPK but not PI3-K/AKT/GSK-3ß signaling pathways were activated by leptin , and that STAT3 ( Y ( 705 ) P-STAT3 ) and MEK ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) mediate these effects