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LEPR — PTPN11

Pathways - manually collected, often from reviews:

• Reactome Reaction: PTPN11 → LEPR (reaction) Carpenter et al., Proc Natl Acad Sci U S A 1998*
• Reactome Reaction: PTPN11 → LEPR (indirect_complex) Carpenter et al., Proc Natl Acad Sci U S A 1998*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: PTPN11 — LEPR (in vivo) Bjorbak et al., J Biol Chem 2000*
• IRef Intact Interaction: PTPN11 — LEPR (association, surface plasmon resonance) Löthgren et al., Biochim Biophys Acta 2001*
• IRef Intact Interaction: PTPN11 — LEPR (association, anti tag coimmunoprecipitation) Carpenter et al., Proc Natl Acad Sci U S A 1998*
• IRef Ophid Interaction: PTPN11 — LEPR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PTPN11 — LEPR (aggregation, confirmational text mining) Bjorbak et al., J Biol Chem 2000*

Text-mined interactions from Literome

Li et al., Proc Natl Acad Sci U S A 1999 (Obesity) : Tyrosyl phosphorylation of the leptin receptor and signal transducer and activater of transcription 3 ( STAT3 ) are not affected by phosphorylation of SHP-2 ... These data suggest that activation of SHP-2 by the leptin receptor results in a decreased phosphorylation of JAK2 and may act to attenuate leptin signal transduction
Carpenter et al., Proc Natl Acad Sci U S A 1998 (Obesity) : Herein we report that activation of ObR induces the tyrosine phosphorylation of the tyrosine phosphatase SH2 containing phosphatase 2 (SHP-2) and demonstrate that Tyr986 within the ObR cytoplasmic domain is essential to mediate phosphorylation of SHP-2 and binding of SHP-2 to ObR