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LFNG — NOTCH2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Hicks et al., Nat Cell Biol 2000
:
Lfng localizes to the Golgi, and Lfng dependent modulation of
Notch signalling
requires both expression of Lfng in the Notch-responsive cell and the Notch extracellular domain
Zhu et al., IEEE Trans Nanobioscience 2006
:
Simulation reveals that the transient block of
Notch by Notch
induced Lfng and the delayed removal of the block by another Notch induced protein Hes7 may explain the observed unidirectional propagation of Notch signaling in these cells
Tan et al., Immunity 2009
:
We show that
Lunatic Fringe (Lfng) and Manic Fringe (Mfng) cooperatively
enhanced the
DL1-Notch2 interaction to promote MZ B cell development
Nikolaou et al., Development 2009
:
The expression of
Lfng does not
require Notch activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors
Kato et al., Mol Cell Neurosci 2010
:
In vivo overexpression experiments with Notch ligands suggest that
Lfng strongly
augments Notch signaling mediated by Delta-like 1 but not Jagged 1
Hou et al., J Biol Chem 2012
:
In mutant Chinese hamster ovary ( CHO ) cells that do not add galactose (Gal) to the GlcNAc transferred by Fringe, JAG1 induced
NOTCH signaling is not
inhibited by
LFNG or MFNG ... Here we show that DLL1 induced
NOTCH signaling in CHO cells was
enhanced by
LFNG , but this did not occur in either Lec8 or Lec20 CHO mutants lacking Gal on O-fucose glycans ... Gal enhances the effect of
LFNG but
inhibits the effect of MFNG on DLL1 induced
NOTCH signaling, with functional consequences for regulating the strength of NOTCH signaling
Gu et al., PloS one 2012
(Asthma...) :
Notch signaling was more activated in asthmatic naïve CD4 ( + ) T cells than in control cells, and
Lfng , but not Mfng or Rfng, partly
inhibited Notch signaling in asthmatic naïve CD4 ( + ) T lymphocytes
Okubo et al., Nature communications 2012
:
By analysing Lunatic fringe (Lfng) chimeric embryos and Notch signal reporter assays using a co-culture system, we further find that
Lfng represses
Notch activity in neighbouring cells by modulating Dll1 function