Gene interactions and pathways from curated databases and text-mining

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LFNG — NOTCH2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hicks et al., Nat Cell Biol 2000 : Lfng localizes to the Golgi, and Lfng dependent modulation of Notch signalling requires both expression of Lfng in the Notch-responsive cell and the Notch extracellular domain
Zhu et al., IEEE Trans Nanobioscience 2006 : Simulation reveals that the transient block of Notch by Notch induced Lfng and the delayed removal of the block by another Notch induced protein Hes7 may explain the observed unidirectional propagation of Notch signaling in these cells
Tan et al., Immunity 2009 : We show that Lunatic Fringe (Lfng) and Manic Fringe (Mfng) cooperatively enhanced the DL1-Notch2 interaction to promote MZ B cell development
Nikolaou et al., Development 2009 : The expression of Lfng does not require Notch activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors
Kato et al., Mol Cell Neurosci 2010 : In vivo overexpression experiments with Notch ligands suggest that Lfng strongly augments Notch signaling mediated by Delta-like 1 but not Jagged 1
Hou et al., J Biol Chem 2012 : In mutant Chinese hamster ovary ( CHO ) cells that do not add galactose (Gal) to the GlcNAc transferred by Fringe, JAG1 induced NOTCH signaling is not inhibited by LFNG or MFNG ... Here we show that DLL1 induced NOTCH signaling in CHO cells was enhanced by LFNG , but this did not occur in either Lec8 or Lec20 CHO mutants lacking Gal on O-fucose glycans ... Gal enhances the effect of LFNG but inhibits the effect of MFNG on DLL1 induced NOTCH signaling, with functional consequences for regulating the strength of NOTCH signaling
Gu et al., PloS one 2012 (Asthma...) : Notch signaling was more activated in asthmatic naïve CD4 ( + ) T cells than in control cells, and Lfng , but not Mfng or Rfng, partly inhibited Notch signaling in asthmatic naïve CD4 ( + ) T lymphocytes
Okubo et al., Nature communications 2012 : By analysing Lunatic fringe (Lfng) chimeric embryos and Notch signal reporter assays using a co-culture system, we further find that Lfng represses Notch activity in neighbouring cells by modulating Dll1 function