Gene interactions and pathways from curated databases and text-mining

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LGR4 — WNT1

Text-mined interactions from Literome

Glinka et al., EMBO Rep 2011 (Wnt Signaling Pathway) : Gain- and loss-of-function experiments in mammalian cells and Xenopus embryos indicate that LGR4 and LGR5 promote R-spondin mediated Wnt/ß-catenin and Wnt/PCP signalling
Deng et al., J Cell Sci 2013 (Wnt Signaling Pathway) : Using newly available genome sequences, we showed that norrin is a vertebrate ortholog for insect burs and pburs and stimulates Wnt signaling mediated by LGR4 , but not by LGR5 and 6, in mammalian cells
Qian et al., Development 2013 (Wnt Signaling Pathway) : Lgr4 mediated Wnt/ß-catenin signaling in peritubular myoid cells is essential for spermatogenesis