Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

LPA — PIK3R1

Text-mined interactions from Literome

Laffargue et al., J Biol Chem 1999 : We have identified adherent cell lines where lysophosphatidic acid (LPA) strongly and rapidly activates the accumulation of PI3K lipid products ... Finally, we show that LPA can not activate PI3K in cell lines lacking the EGFR/Gab1 pathway, including cells that transactivate the PDGF receptor ... Altogether, these results demonstrate that activation of PI3K by LPA is conditioned by the ability of LPA to transactivate an EGFR/Gab1 signaling pathway
Estrella et al., Int J Oncol 2007 (MAP Kinase Signaling System...) : LPA stimulation of ovarian cancer cells markedly increased the phosphorylation and activity of p38 ( MAPK ), p42/p44(MAPK), and PI3K
Kim et al., Exp Mol Med 2008 (Ascites...) : Both LPA- and AOCP induced MEF cell migration was completely attenuated by PI3K inhibitor, LY294002
Ambesi et al., Mol Cancer Res 2009 : Both LPA and S1P activated PI3K , Ras/ERK, and Rho/Rho kinase pathways, leading to migration, G ( 1 ) -S cell cycle progression, and stress fiber formation, respectively ... Although LPA and S1P activated both PI3K/Akt and Ras/ERK signaling through G ( i ), anastellin inhibited only the Ras/ERK pathway