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LPA — PIK3R1
Text-mined interactions from Literome
Laffargue et al., J Biol Chem 1999
:
We have identified adherent cell lines where
lysophosphatidic acid (LPA) strongly and rapidly
activates the accumulation of
PI3K lipid products ... Finally, we show that
LPA can not
activate PI3K in cell lines lacking the EGFR/Gab1 pathway, including cells that transactivate the PDGF receptor ... Altogether, these results demonstrate that
activation of
PI3K by
LPA is conditioned by the ability of LPA to transactivate an EGFR/Gab1 signaling pathway
Estrella et al., Int J Oncol 2007
(MAP Kinase Signaling System...) :
LPA stimulation of ovarian cancer cells markedly
increased the phosphorylation and activity of p38 ( MAPK ), p42/p44(MAPK), and
PI3K
Kim et al., Exp Mol Med 2008
(Ascites...) :
Both
LPA- and AOCP induced MEF cell migration was completely
attenuated by
PI3K inhibitor, LY294002
Ambesi et al., Mol Cancer Res 2009
:
Both
LPA and S1P
activated PI3K , Ras/ERK, and Rho/Rho kinase pathways, leading to migration, G ( 1 ) -S cell cycle progression, and stress fiber formation, respectively ... Although
LPA and S1P
activated both
PI3K/Akt and Ras/ERK signaling through G ( i ), anastellin inhibited only the Ras/ERK pathway