Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — LRP6

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Mao et al., Nature 2001 : Dkk1 blocks LRP6 mediated Wnt/beta-catenin signalling by interacting with domains that are distinct from those required for Wnt/Frizzled interaction
Semënov et al., Curr Biol 2001 : Our findings suggest that Wnt-Fz-LRP6 complex formation, but not Wnt-Fz interaction, triggers Wnt/beta-catenin signaling
Cong et al., Development 2004 : In addition, the beta-catenin signaling mediated by ectopic expression of LRP is not dependent on Disheveled or Wnt, but can also be augmented by oligomerization of LRP receptors
Swiatek et al., J Biol Chem 2006 : Two of the identified phosphorylation sites, Ser1420 and Ser1430, influence Wnt signaling in vivo, since LRP6 with mutation of these sites is a more potent activator of both beta-catenin accumulation and Lef-1 reporter activity
Mukhopadhyay et al., Development 2006 : The Dkk family of secreted cysteine-rich proteins regulates Wnt/beta-catenin signaling by interacting with the Wnt co-receptor Lrp5/6
Yamamoto et al., Dev Cell 2006 : Here, we present evidence that LRP6 is internalized with caveolin and that the components of this endocytic pathway are required not only for Wnt-3a induced internalization of LRP6 but also for accumulation of beta-catenin ... Overall, our data suggest that Wnt-3a triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta and that caveolin thereby inhibits the binding of beta-catenin to Axin
Kofron et al., Development 2007 : Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6 mediated regulation of axin ... In the oocyte, Wnt11 and/or LRP6 regulates axin to maintain beta-catenin at a low level, while in the embryo, asymmetrical Wnt11/LRP6 signaling stabilizes beta-catenin and enriches it on the dorsal side
Bhat et al., Gene 2007 : In the presence of Wnt1, LRP5 or the HBM variant ( LRP5-G171V ) induces beta-catenin nuclear translocation and activates T cell factor ( TCF ) -luciferase reporter activity
Tahinci et al., Development 2007 : We propose a model in which Lrp6 plays a critical role in the switch from Wnt/PCP to Wnt/beta-catenin signaling
Zeng et al., Development 2008 : We demonstrated previously that Wnt induced Lrp6 phosphorylation via glycogen synthase kinase 3 ( Gsk3 ) initiates Wnt/beta-catenin signaling
Cselenyi et al., Proc Natl Acad Sci U S A 2008 : Using an Axin mutant that does not degrade in response to LRP6, we demonstrate that LRP6 can stabilize beta-catenin in the absence of Axin turnover ... Through experiments in egg extract and reconstitution with purified proteins, we identify a mechanism whereby LRP6 stabilizes beta-catenin independently of Axin degradation by directly inhibiting GSK3 's phosphorylation of beta-catenin
Yamamoto et al., Dev Cell 2008 : The phosphorylation and internalization of LRP6 occurred independently of one another, and both were necessary for the accumulation of beta-catenin ... These results indicate that Wnt3a and Dkk1 shunt LRP6 to distinct internalization pathways in order to activate and inhibit the beta-catenin signaling, respectively
Beagle et al., J Cell Biochem 2009 : LRP6-ICD and a mutant in which all 5 PPP ( S/T ) P motifs were changed to PPP ( A ) P motifs equivalently interacted with and attenuated GSK3beta activity in vitro, and both constructs inhibited the in situ GSK3beta mediated phosphorylation of beta-catenin and tau to the same extent
Lu et al., Biochemistry 2010 : Mesd not only blocks binding of Wnt antagonists Dkk1 and Sclerostin to LRP5 and LRP6 but also inhibits Wnt3A and Rspondin1 induced Wnt/beta-catenin signaling in LRP5- and LRP6 expressing cells